Usefulness of limited sampling strategy for mycophenolic acid area under the curve considering postoperative days in living-donor renal transplant recipients with concomitant prolonged-release tacrolimus

Table 2 Correlation with measured AUC_0-12, accuracy, and reliability of each estimated formula

		n	Equations for AUC_0-12 estimation	P value^*	RMSE^**	R^2#	q^{2 ##}
Method A	All patients	100	7.4 + 2.3 × C_0h + 1.2 × C_1h + 2.3 × C_3h + 4.4 × C_6h	<0.0001	5.5	0.85	0.83
Method B	POD < 31	39	10.6 + 1.1 × C_1h + 1.1 × C_2h + 2.0 × C_4h + 3.9 × C_6h	< 0.0001	5.5	0.86	0.83
Method B	POD ≥ 31	61	3.8 + 3.5 × C_0h + 1.2 × C_1h + 1.9 × C_3h + 5.4 × C_6h	< 0.0001	3.9	0.92	0.89

C _time serum mycophenolic acid concentration at time after administration, POD postoperative day
*P value: Spearman’s rank correlation test, **RMSE root-mean-square error, ^# R ² least squares method, ^## q ² leave-one-out cross-validation

ISSN: 2055-0294