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Table 5 Comparison of 4vHPV versus other HPV vaccines regarding solicited local and systemic symptoms

From: Safety of human papillomavirus vaccines in healthy young women: a meta-analysis of 24 controlled studies

Components

Studies, n

Subjects, n

Pooled RR [95% CI]

Reference

Pain

3

1845

0.89 [0.75, 1.05]

[28, 29, 45]

Redness

2

1246

0.70 [0.46, 1.07]

[28, 29]

Swelling

3

1845

0.71 [0.57, 0.88]

[28, 29, 45]

Fatigue

2

1250

0.82 [0.73, 0.92]

[28, 29]

  1. Other HPV vaccines stand for 2vHPV and 9vHPV
  2. Two studies [28, 29] compare 4vHPV with 2vHPV and one study [45] compares 4vHPV with 9vHPV
  3. Abbreviations: HPV human papillomavirus, 2vHPV bivalent human papillomavirus, 4vHPV quadrivalent human papillomavirus, RR risk ratio, CI confidence interval