Table 1 Grading of peripheral sensory neuropathy by the CTCAE ver. 4.0 and PNQ

Grade 1

Grade 2

Grade 3

Grade 4

Grade 5

CTC-AE ver 4.0

Asymptomatic; loss of deep tendon reflexes or paresthesia

Moderate symptoms; limiting instrumental ADL

Severe symptoms; limiting self care ADL

Life-threatening consequences; urgent intervention indicated

Death

Scale A

Scale B

Scale C

Scale D

Scale E

PNQ

I have no numbness, pain or tingling in my hand

I have mild tingling, pain or numbness in my hand. This dose not interfere with my ADL.

I have moderate tingling, pain or numbness in my hand. This dose not interfere with my ADL.

I have moderate to severe tingling, pain or numbness in my hand. This interferes with my ADL.

I have severe tingling, pain or numbness in my hand. It completely prevents me from doing most ADL.