Fig. 2

TJ24 and TJ68 with NGF improved paclitaxel-induced neuropathy morphologically and functionally. Recovery of neurites from paclitaxel-induced regression after 72 h exposure to TJ24, TJ68, NGF plus TJ24, TJ68, or TJ107 was assessed. In terms of neurite length (a), expression of GAP-43 (b), NF-L (c), and acetylcholine esterase concentration (d), treatment with NGF and TJ24 or TJ68 promoted neurite outgrowth significantly compared to NGF alone. Results (mean ± S.E.) are representative of three independent experiments (n = 3). * p < 0.05. NGF: nerve growth factor; GAP-43: growth-associated protein 43; NF-L: light neurofilament; SE: standard error