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Fig. 2 | Journal of Pharmaceutical Health Care and Sciences

Fig. 2

From: Developmental changes of fluconazole clearance in neonates and infants in relation to ontogeny of glomerular filtration rate: literature review and data analysis

Fig. 2

Relationship between fluconazole clearance normalized to body surface area (BSA) (CLBSA) and postmenstrual age (PMA) in neonates and infants (a) and between fluconazole CLBSA and age in children older than 5 years and adults (b). The area of each symbol (â—‹) is in proportion to the number of dataset. BSA of premature infants and neonates was estimated by Haycock’s formula, and that of children and adults by Dubois’s formula. There is a significant correlation between fluconazole CLBSA and PMA in neonates and infants (Y = 0.263X -4.92, r = 0.68, p < 0.001), and between fluconazole CLBSA and age in young children and adults (Y = − 0.097X + 14.22, r = − 0.36, p < 0.005). Solid lines represent the least square regression lines. Bold dotted lines represent the upper and lower 95% confidence intervals of the regression lines. Fine dotted lines represent the 95% confidence intervals of all datasets

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