Fig. 3From: Developmental changes of fluconazole clearance in neonates and infants in relation to ontogeny of glomerular filtration rate: literature review and data analysisRelationships between fluconazole clearance normalized to body weight (BW) (CLBW) and postmenstrual age (PMA) in neonates and infants (a) and between fluconazole CLBW and age in children older than 5 years and adults (b). The area of each symbol (○) is in proportion to the number of datasets. There is a significant correlation between fluconazole CLBW and PMA in neonates and infants (Y = 0.011X – 0.04, r = 0.46, p < 0.005), and between fluconazole CLBW and age in young children and adults (Y = − 0.006X + 0.50, r = − 0.60, p < 0.001). Solid lines represent the least square regression lines. Bold dotted lines represent the upper and lower 95% confidence intervals of the regression lines. Fine dotted lines represent the 95% confidence intervals of all datasetsBack to article page