Fig. 4

Developmental time courses of unadjusted glomerular filtration rate (GFR) (a) and GFR normalized to body surface area (BSA) of 1.73m² (GFR_BSA) (b) as a function of PMA in neonates, infants, and children. The original datasets were retrieved from the reports of Rubin et al. (40), Coulthard et al. (42), Fawer et al. (41) and van der Heijden et al. (43). Details of the sigmoidal hyperbolic model are described in the text