Total score | Subscale | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adverse event | Existence of intervention | n | Before 1st course | Before 2nd course | Difference | P | Activity | P | Physical condition | P | Psychological condition | P | Social relationships | P | ||||||||
Before 1st course | Before 2nd course | Difference | Before 1st course | Before 2nd course | Difference | Before 1st course | Before 2nd course | Difference | Before 1st course | Before 2nd course | Difference | |||||||||||
(A) | (B) | (B-A) | (A) | (B) | (B-A) | (A) | (B) | (B-A) | (A) | (B) | (B-A) | (A) | (B) | (B-A) | ||||||||
Constipation | Non intervention | 8 | 87.75 ± 12.93 | 77.63 ± 19.40 | −10.13 ± 13.10 | 0.481 | 4.67 ± 0.59 | 3.52 ± 1.16 | −1.15 ± 1.01 | 0.277 | 4.40 ± 0.62 | 3.67 ± 0.86 | −0.73 ± 0.58 | 0.321 | 4.00 ± 0.66 | 3.50 ± 0.90 | − 0.50 ± 0.55 | 0.606 | 2.03 ± 0.96 | 2.75 ± 0.76 | 0.73 ± 0.63 | 0.200 |
Intervention | 9 | 92.56 ± 12.37 | 87.56 ± 13.67 | −5.00 ± 7.09 | 4.70 ± 0.83 | 4.15 ± 0.92 | −0.56 ± 0.54 | 4.50 ± 0.38 | 4.11 ± 0.24 | − 0.39 ± 0.37 | 4.07 ± 0.77 | 3.78 ± 1.00 | − 0.29 ± 0.90 | 2.69 ± 0.68 | 3.04 ± 0.67 | 0.36 ± 0.42 | ||||||
Nausea | Non intervention | 10 | 83.20 ± 13.18 | 77.70 ± 14.60 | −5.50 ± 10.78 | 0.875 | 4.43 ± 0.79 | 3.72 ± 0.99 | − 0.72 ± 0.82 | 1.000 | 4.10 ± 0.81 | 3.65 ± 0.70 | − 0.45 ± 0.73 | 0.313 | 3.84 ± 0.65 | 3.56 ± 0.81 | − 0.28 ± 0.51 | 1.000 | 2.00 ± 0.71 | 2.50 ± 0.58 | 0.50 ± 0.65 | 0.263 |
Intervention | 6 | 91.17 ± 5.67 | 87.67 ± 13.10 | −3.50 ± 11.57 | 5.00 ± 0.00 | 4.22 ± 0.75 | − 0.78 ± 0.75 | 4.33 ± 0.71 | 4.00 ± 0.81 | − 0.33 ± 0.26 | 4.20 ± 0.62 | 3.90 ± 0.83 | − 0.30 ± 1.02 | 2.07 ± 0.63 | 3.07 ± 0.69 | 1.00 ± 0.89 | ||||||
Oral pain | Non intervention | 9 | 87.33 ± 15.57 | 83.89 ± 17.50 | −3.44 ± 7.96 | 0.408 | 4.52 ± 0.71 | 3.94 ± 3.94 | − 0.57 ± 0.69 | 0.351 | 4.24 ± 0.94 | 3.93 ± 0.76 | − 0.31 ± 0.68 | 0.758 | 4.02 ± 0.76 | 3.80 ± 1.02 | − 0.22 ± 0.39 | 0.918 | 2.33 ± 0.85 | 2.82 ± 0.61 | 0.49 ± 0.67 | 1.000 |
Intervention | 7 | 95.29 ± 6.18 | 89.14 ± 7.69 | −6.14 ± 7.82 | 4.88 ± 0.25 | 4.05 ± 0.57 | − 0.83 ± 0.54 | 4.33 ± 0.46 | 4.07 ± 0.46 | − 0.26 ± 0.53 | 4.23 ± 0.45 | 3.97 0.42 | −0.26 ± 0.70 | 3.00 ± 0.42 | 3.40 ± 0.54 | 0.40 ± 0.74 | ||||||
Vomiting | Non intervention | 5 | 85.60 ± 7.80 | 78.20 ± 10.62 | −7.40 ± 7.67 | 0.571 | 4.53 ± 0.73 | 3.93 ± 0.80 | −0.60 ± 0.91 | 1.000 | 4.40 ± 0.30 | 3.60 ± 0.48 | − 0.80 ± 0.22 | 0.190 | 3.84 ± 0.61 | 3.48 ± 0.92 | − 0.36 ± 0.41 | 0.571 | 2.00 ± 0.57 | 2.36 ± 0.46 | 0.36 ± 0.61 | 0.095 |
Intervention | 2 | 93.00 ± 2.83 | 94.50 ± 16.26 | 1.50 ± 13.44 | 5.00 ± 0.00 | 4.33 ± 0.94 | −0.67 ± 0.94 | 4.50 ± 0.71 | 4.08 ± 1.06 | − 0.42 ± 0.35 | 4.40 ± 0.85 | 4.30 ± 0.99 | − 0.10 ± 0.14 | 1.90 ± 1.27 | 3.90 ± 0.42 | 2.00 ± 0.85 | ||||||
Fever | Non intervention | 4 | 94.50 ± 7.94 | 97.50 ± 7.51 | 3.00 ± 2.94 | 0.114 | 5.00 ± 0.00 | 4.92 ± 0.10 | −0.08 ± 0.10 | 0.257 | 4.75 ± 0.29 | 4.50 ± 0.41 | − 0.25 ± 0.17 | 0.352 | 4.40 ± 0.54 | 4.60 ± 0.43 | 0.20 ± 0.23 | 0.476 | 2.05 ± 0.76 | 2.85 ± 0.64 | 0.80 ± 0.67 | 0.476 |
Intervention | 6 | 89.83 ± 14.36 | 87.17 ± 16.08 | −2.67 ± 5.43 | 4.53 ± 1.00 | 4.03 ± 1.04 | −0.50 ± 0.45 | 4.58 ± 0.36 | 4.03 ± 0.32 | − 0.56 ± 0.43 | 3.90 ± 0.75 | 3.87 ± 1.19 | − 0.03 ± 0.69 | 2.43 ± 0.78 | 3.07 ± 0.64 | 0.63 ± 0.46 | ||||||
Malaise | Non intervention | 12 | 87.42 ± 11.40 | 79.58 ± 16.00 | −7.83 ± 10.90 | 0.069 | 4.64 ± 0.64 | 3.78 ± 1.02 | −0.86 ± 0.95 | 0.254 | 4.39 ± 0.50 | 3.72 ± 0.76 | − 0.67 ± 0.54 | 0.159 | 4.02 ± 0.55 | 3.72 ± 0.82 | − 0.30 ± 0.54 | 0.203 | 2.03 ± 0.85 | 2.53 ± 0.67 | 0.50 ± 0.66 | 0.043* |
Intervention | 10 | 86.00 ± 8.83 | 88.10 ± 13.88 | 2.10 ± 7.97 | 4.67 ± 0.78 | 4.23 ± 0.95 | −0.43 ± 0.64 | 4.40 ± 0.55 | 4.07 ± 0.66 | −0.33 ± 0.41 | 3.74 ± 0.56 | 3.84 ± 0.95 | 0.10 ± 0.63 | 1.86 ± 0.65 | 3.10 ± 0.57 | 1.24 ± 0.85 | ||||||
Anorexia | Non intervention | 10 | 81.60 ± 11.51 | 73.30 ± 12.62 | −8.30 ± 12.00 | 0.152 | 4.43 ± 0.79 | 3.48 ± 1.02 | −0.95 ± 1.01 | 0.152 | 4.08 ± 0.79 | 3.45 ± 0.60 | −0.63 ± 0.83 | 0.099 | 3.76 ± 0.59 | 3.36 ± 0.71 | − 0.40 ± 0.52 | 0.099 | 1.80 ± 0.60 | 2.38 ± 0.44 | 0.58 ± 0.69 | 0.468 |
Intervention | 11 | 90.64 ± 8.16 | 90.82 ± 9.02 | 0.18 ± 7.31 | 4.92 ± 0.16 | 4.47 ± 0.60 | −0.45 ± 0.63 | 4.39 ± 0.54 | 4.09 ± 0.60 | − 0.30 ± 0.45 | 3.84 ± 0.56 | 3.95 ± 0.51 | 0.11 ± 0.64 | 2.36 ± 0.79 | 3.22 ± 0.60 | 0.85 ± 0.82 | ||||||
Peripheral sensory neuropathy | Non intervention | 3 | 80.67 ± 8.39 | 75.33 ± 8.74 | −5.33 ± 17.01 | 0.571 | 4.33 ± 0.67 | 3.61 ± 0.77 | −0.72 ± 1.39 | 0.571 | 4.22 ± 0.42 | 4.00 ± 0.83 | − 0.22 ± 1.07 | 1.000 | 3.20 ± 0.53 | 2.73 ± 0.46 | − 0.47 ± 0.58 | 0.571 | 2.07 ± 0.50 | 2.47 ± 0.46 | 0.40 ± 0.20 | 0.250 |
Intervention | 5 | 85.60 ± 12.38 | 82.80 ± 14.34 | −2.80 ± 6.98 | 4.43 ± 1.08 | 3.90 ± 1.07 | −0.53 ± 0.40 | 4.43 ± 0.15 | 4.03 ± 0.46 | −0.40 ± 0.52 | 3.64 ± 0.50 | 3.44 ± 1.03 | − 0.20 ± 0.60 | 2.20 ± 1.01 | 2.88 ± 0.33 | 0.68 ± 1.01 | ||||||
Alopecia | Non intervention | 17 | 90.06 ± 12.86 | 85.35 ± 17.08 | −4.71 ± 10.42 | 0.876 | 4.75 ± 0.56 | 4.01 ± 1.01 | −0.74 ± 0.81 | 0.616 | 4.38 ± 0.71 | 4.04 ± 0.77 | −0.34 ± 0.68 | 0.925 | 4.02 ± 0.64 | 3.87 ± 0.86 | − 0.15 ± 0.52 | 0.851 | 2.37 ± 0.95 | 2.84 ± 0.72 | 0.47 ± 0.62 | 0.573 |
Intervention | 19 | 91.74 ± 9.92 | 89.26 ± 11.67 | −2.47 ± 8.09 | 4.79 ± 0.58 | 4.25 ± 0.76 | −0.54 ± 0.57 | 4.43 ± 0.51 | 4.11 ± 0.50 | −0.32 ± 0.47 | 4.05 ± 0.66 | 3.94 ± 0.79 | − 0.12 ± 0.73 | 2.50 ± 0.83 | 3.15 ± 0.64 | 0.65 ± 0.90 | ||||||
Nail ridging | Non intervention | 3 | 93.67 ± 9.29 | 87.00 ± 17.06 | −6.67 ± 10.02 | 0.629 | 4.89 ± 0.19 | 4.22 ± 0.92 | −0.67 ± 1.01 | 0.857 | 4.50 ± 0.33 | 3.89 ± 0.67 | −0.61 ± 0.35 | 1.000 | 4.13 ± 0.99 | 3.80 ± 1.39 | − 0.33 ± 0.42 | 0.229 | 2.60 ± 1.20 | 3.13 ± 0.61 | 0.53 ± 0.61 | 0.400 |
Intervention | 4 | 92.75 ± 9.74 | 92.00 ± 11.46 | −0.75 ± 5.74 | 4.75 ± 0.29 | 4.13 ± 0.60 | − 0.63 ± 0.44 | 4.42 ± 0.57 | 4.13 ± 0.44 | − 0.29 ± 0.90 | 4.10 ± 0.62 | 4.15 0.74 | 0.05 ± 0.34 | 2.65 ± 0.77 | 3.50 ± 0.62 | 0.85 ± 0.25 | ||||||
Skin disorder | Non intervention | 9 | 91.33 ± 14.26 | 84.56 ± 19.74 | −6.78 ± 10.27 | 0.606 | 4.70 ± 0.56 | 3.89 ± 1.10 | − 0.81 ± 0.83 | 0.606 | 4.44 ± 0.66 | 3.98 ± 0.89 | − 0.46 ± 0.41 | 0.815 | 4.11 ± 0.71 | 3.80 ± 0.97 | − 0.31 ± 0.53 | 0.743 | 2.44 ± 1.00 | 2.91 ± 0.82 | 0.47 ± 0.63 | 0.321 |
Intervention | 8 | 90.00 ± 8.65 | 87.63 ± 9.61 | −2.38 ± 10.32 | 4.83 ± 0.27 | 4.25 ± 0.70 | − 0.58 ± 0.73 | 4.27 ± 0.59 | 3.98 ± 0.58 | − 0.29 ± 0.60 | 4.00 ± 0.57 | 3.75 ± 0.44 | − 0.25 ± 0.67 | 2.35 ± 0.95 | 3.18 ± 0.50 | 0.83 ± 1.05 |