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Table 4 Comparison of the QOL-ACD total score and mean score for each subscale before 1st and 2nd course in patients with adverse events of both groups

From: Impact of pharmacist counseling on reducing instances of adverse events that can affect the quality of life of chemotherapy outpatients with breast Cancer

   

Total score

Subscale

Adverse event

Existence of intervention

n

Before 1st course

Before 2nd course

Difference

P

Activity

P

Physical condition

P

Psychological condition

P

Social relationships

P

Before 1st course

Before 2nd course

Difference

Before 1st course

Before 2nd course

Difference

Before 1st course

Before 2nd course

Difference

Before 1st course

Before 2nd course

Difference

(A)

(B)

(B-A)

(A)

(B)

(B-A)

(A)

(B)

(B-A)

(A)

(B)

(B-A)

(A)

(B)

(B-A)

Constipation

Non intervention

8

87.75 ± 12.93

77.63 ± 19.40

−10.13 ± 13.10

0.481

4.67 ± 0.59

3.52 ± 1.16

−1.15 ± 1.01

0.277

4.40 ± 0.62

3.67 ± 0.86

−0.73 ± 0.58

0.321

4.00 ± 0.66

3.50 ± 0.90

− 0.50 ± 0.55

0.606

2.03 ± 0.96

2.75 ± 0.76

0.73 ± 0.63

0.200

Intervention

9

92.56 ± 12.37

87.56 ± 13.67

−5.00 ± 7.09

 

4.70 ± 0.83

4.15 ± 0.92

−0.56 ± 0.54

 

4.50 ± 0.38

4.11 ± 0.24

− 0.39 ± 0.37

 

4.07 ± 0.77

3.78 ± 1.00

− 0.29 ± 0.90

 

2.69 ± 0.68

3.04 ± 0.67

0.36 ± 0.42

 

Nausea

Non intervention

10

83.20 ± 13.18

77.70 ± 14.60

−5.50 ± 10.78

0.875

4.43 ± 0.79

3.72 ± 0.99

− 0.72 ± 0.82

1.000

4.10 ± 0.81

3.65 ± 0.70

− 0.45 ± 0.73

0.313

3.84 ± 0.65

3.56 ± 0.81

− 0.28 ± 0.51

1.000

2.00 ± 0.71

2.50 ± 0.58

0.50 ± 0.65

0.263

Intervention

6

91.17 ± 5.67

87.67 ± 13.10

−3.50 ± 11.57

 

5.00 ± 0.00

4.22 ± 0.75

− 0.78 ± 0.75

 

4.33 ± 0.71

4.00 ± 0.81

− 0.33 ± 0.26

 

4.20 ± 0.62

3.90 ± 0.83

− 0.30 ± 1.02

 

2.07 ± 0.63

3.07 ± 0.69

1.00 ± 0.89

 

Oral pain

Non intervention

9

87.33 ± 15.57

83.89 ± 17.50

−3.44 ± 7.96

0.408

4.52 ± 0.71

3.94 ± 3.94

− 0.57 ± 0.69

0.351

4.24 ± 0.94

3.93 ± 0.76

− 0.31 ± 0.68

0.758

4.02 ± 0.76

3.80 ± 1.02

− 0.22 ± 0.39

0.918

2.33 ± 0.85

2.82 ± 0.61

0.49 ± 0.67

1.000

Intervention

7

95.29 ± 6.18

89.14 ± 7.69

−6.14 ± 7.82

 

4.88 ± 0.25

4.05 ± 0.57

− 0.83 ± 0.54

 

4.33 ± 0.46

4.07 ± 0.46

− 0.26 ± 0.53

 

4.23 ± 0.45

3.97 0.42

−0.26 ± 0.70

 

3.00 ± 0.42

3.40 ± 0.54

0.40 ± 0.74

 

Vomiting

Non intervention

5

85.60 ± 7.80

78.20 ± 10.62

−7.40 ± 7.67

0.571

4.53 ± 0.73

3.93 ± 0.80

−0.60 ± 0.91

1.000

4.40 ± 0.30

3.60 ± 0.48

− 0.80 ± 0.22

0.190

3.84 ± 0.61

3.48 ± 0.92

− 0.36 ± 0.41

0.571

2.00 ± 0.57

2.36 ± 0.46

0.36 ± 0.61

0.095

Intervention

2

93.00 ± 2.83

94.50 ± 16.26

1.50 ± 13.44

 

5.00 ± 0.00

4.33 ± 0.94

−0.67 ± 0.94

 

4.50 ± 0.71

4.08 ± 1.06

− 0.42 ± 0.35

 

4.40 ± 0.85

4.30 ± 0.99

− 0.10 ± 0.14

 

1.90 ± 1.27

3.90 ± 0.42

2.00 ± 0.85

 

Fever

Non intervention

4

94.50 ± 7.94

97.50 ± 7.51

3.00 ± 2.94

0.114

5.00 ± 0.00

4.92 ± 0.10

−0.08 ± 0.10

0.257

4.75 ± 0.29

4.50 ± 0.41

− 0.25 ± 0.17

0.352

4.40 ± 0.54

4.60 ± 0.43

0.20 ± 0.23

0.476

2.05 ± 0.76

2.85 ± 0.64

0.80 ± 0.67

0.476

Intervention

6

89.83 ± 14.36

87.17 ± 16.08

−2.67 ± 5.43

 

4.53 ± 1.00

4.03 ± 1.04

−0.50 ± 0.45

 

4.58 ± 0.36

4.03 ± 0.32

− 0.56 ± 0.43

 

3.90 ± 0.75

3.87 ± 1.19

− 0.03 ± 0.69

 

2.43 ± 0.78

3.07 ± 0.64

0.63 ± 0.46

 

Malaise

Non intervention

12

87.42 ± 11.40

79.58 ± 16.00

−7.83 ± 10.90

0.069

4.64 ± 0.64

3.78 ± 1.02

−0.86 ± 0.95

0.254

4.39 ± 0.50

3.72 ± 0.76

− 0.67 ± 0.54

0.159

4.02 ± 0.55

3.72 ± 0.82

− 0.30 ± 0.54

0.203

2.03 ± 0.85

2.53 ± 0.67

0.50 ± 0.66

0.043*

Intervention

10

86.00 ± 8.83

88.10 ± 13.88

2.10 ± 7.97

 

4.67 ± 0.78

4.23 ± 0.95

−0.43 ± 0.64

 

4.40 ± 0.55

4.07 ± 0.66

−0.33 ± 0.41

 

3.74 ± 0.56

3.84 ± 0.95

0.10 ± 0.63

 

1.86 ± 0.65

3.10 ± 0.57

1.24 ± 0.85

 

Anorexia

Non intervention

10

81.60 ± 11.51

73.30 ± 12.62

−8.30 ± 12.00

0.152

4.43 ± 0.79

3.48 ± 1.02

−0.95 ± 1.01

0.152

4.08 ± 0.79

3.45 ± 0.60

−0.63 ± 0.83

0.099

3.76 ± 0.59

3.36 ± 0.71

− 0.40 ± 0.52

0.099

1.80 ± 0.60

2.38 ± 0.44

0.58 ± 0.69

0.468

Intervention

11

90.64 ± 8.16

90.82 ± 9.02

0.18 ± 7.31

 

4.92 ± 0.16

4.47 ± 0.60

−0.45 ± 0.63

 

4.39 ± 0.54

4.09 ± 0.60

− 0.30 ± 0.45

 

3.84 ± 0.56

3.95 ± 0.51

0.11 ± 0.64

 

2.36 ± 0.79

3.22 ± 0.60

0.85 ± 0.82

 

Peripheral sensory neuropathy

Non intervention

3

80.67 ± 8.39

75.33 ± 8.74

−5.33 ± 17.01

0.571

4.33 ± 0.67

3.61 ± 0.77

−0.72 ± 1.39

0.571

4.22 ± 0.42

4.00 ± 0.83

− 0.22 ± 1.07

1.000

3.20 ± 0.53

2.73 ± 0.46

− 0.47 ± 0.58

0.571

2.07 ± 0.50

2.47 ± 0.46

0.40 ± 0.20

0.250

Intervention

5

85.60 ± 12.38

82.80 ± 14.34

−2.80 ± 6.98

 

4.43 ± 1.08

3.90 ± 1.07

−0.53 ± 0.40

 

4.43 ± 0.15

4.03 ± 0.46

−0.40 ± 0.52

 

3.64 ± 0.50

3.44 ± 1.03

− 0.20 ± 0.60

 

2.20 ± 1.01

2.88 ± 0.33

0.68 ± 1.01

 

Alopecia

Non intervention

17

90.06 ± 12.86

85.35 ± 17.08

−4.71 ± 10.42

0.876

4.75 ± 0.56

4.01 ± 1.01

−0.74 ± 0.81

0.616

4.38 ± 0.71

4.04 ± 0.77

−0.34 ± 0.68

0.925

4.02 ± 0.64

3.87 ± 0.86

− 0.15 ± 0.52

0.851

2.37 ± 0.95

2.84 ± 0.72

0.47 ± 0.62

0.573

Intervention

19

91.74 ± 9.92

89.26 ± 11.67

−2.47 ± 8.09

 

4.79 ± 0.58

4.25 ± 0.76

−0.54 ± 0.57

 

4.43 ± 0.51

4.11 ± 0.50

−0.32 ± 0.47

 

4.05 ± 0.66

3.94 ± 0.79

− 0.12 ± 0.73

 

2.50 ± 0.83

3.15 ± 0.64

0.65 ± 0.90

 

Nail ridging

Non intervention

3

93.67 ± 9.29

87.00 ± 17.06

−6.67 ± 10.02

0.629

4.89 ± 0.19

4.22 ± 0.92

−0.67 ± 1.01

0.857

4.50 ± 0.33

3.89 ± 0.67

−0.61 ± 0.35

1.000

4.13 ± 0.99

3.80 ± 1.39

− 0.33 ± 0.42

0.229

2.60 ± 1.20

3.13 ± 0.61

0.53 ± 0.61

0.400

Intervention

4

92.75 ± 9.74

92.00 ± 11.46

−0.75 ± 5.74

 

4.75 ± 0.29

4.13 ± 0.60

− 0.63 ± 0.44

 

4.42 ± 0.57

4.13 ± 0.44

− 0.29 ± 0.90

 

4.10 ± 0.62

4.15 0.74

0.05 ± 0.34

 

2.65 ± 0.77

3.50 ± 0.62

0.85 ± 0.25

 

Skin disorder

Non intervention

9

91.33 ± 14.26

84.56 ± 19.74

−6.78 ± 10.27

0.606

4.70 ± 0.56

3.89 ± 1.10

− 0.81 ± 0.83

0.606

4.44 ± 0.66

3.98 ± 0.89

− 0.46 ± 0.41

0.815

4.11 ± 0.71

3.80 ± 0.97

− 0.31 ± 0.53

0.743

2.44 ± 1.00

2.91 ± 0.82

0.47 ± 0.63

0.321

Intervention

8

90.00 ± 8.65

87.63 ± 9.61

−2.38 ± 10.32

 

4.83 ± 0.27

4.25 ± 0.70

− 0.58 ± 0.73

 

4.27 ± 0.59

3.98 ± 0.58

− 0.29 ± 0.60

 

4.00 ± 0.57

3.75 ± 0.44

− 0.25 ± 0.67

 

2.35 ± 0.95

3.18 ± 0.50

0.83 ± 1.05

 
  1. Mann-Whitney's U-test, mean±standard deviation, * P < 0.05