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Table 4 Comparison of the QOL-ACD total score and mean score for each subscale before 1st and 2nd course in patients with adverse events of both groups

From: Impact of pharmacist counseling on reducing instances of adverse events that can affect the quality of life of chemotherapy outpatients with breast Cancer

    Total score Subscale
Adverse event Existence of intervention n Before 1st course Before 2nd course Difference P Activity P Physical condition P Psychological condition P Social relationships P
Before 1st course Before 2nd course Difference Before 1st course Before 2nd course Difference Before 1st course Before 2nd course Difference Before 1st course Before 2nd course Difference
(A) (B) (B-A) (A) (B) (B-A) (A) (B) (B-A) (A) (B) (B-A) (A) (B) (B-A)
Constipation Non intervention 8 87.75 ± 12.93 77.63 ± 19.40 −10.13 ± 13.10 0.481 4.67 ± 0.59 3.52 ± 1.16 −1.15 ± 1.01 0.277 4.40 ± 0.62 3.67 ± 0.86 −0.73 ± 0.58 0.321 4.00 ± 0.66 3.50 ± 0.90 − 0.50 ± 0.55 0.606 2.03 ± 0.96 2.75 ± 0.76 0.73 ± 0.63 0.200
Intervention 9 92.56 ± 12.37 87.56 ± 13.67 −5.00 ± 7.09   4.70 ± 0.83 4.15 ± 0.92 −0.56 ± 0.54   4.50 ± 0.38 4.11 ± 0.24 − 0.39 ± 0.37   4.07 ± 0.77 3.78 ± 1.00 − 0.29 ± 0.90   2.69 ± 0.68 3.04 ± 0.67 0.36 ± 0.42  
Nausea Non intervention 10 83.20 ± 13.18 77.70 ± 14.60 −5.50 ± 10.78 0.875 4.43 ± 0.79 3.72 ± 0.99 − 0.72 ± 0.82 1.000 4.10 ± 0.81 3.65 ± 0.70 − 0.45 ± 0.73 0.313 3.84 ± 0.65 3.56 ± 0.81 − 0.28 ± 0.51 1.000 2.00 ± 0.71 2.50 ± 0.58 0.50 ± 0.65 0.263
Intervention 6 91.17 ± 5.67 87.67 ± 13.10 −3.50 ± 11.57   5.00 ± 0.00 4.22 ± 0.75 − 0.78 ± 0.75   4.33 ± 0.71 4.00 ± 0.81 − 0.33 ± 0.26   4.20 ± 0.62 3.90 ± 0.83 − 0.30 ± 1.02   2.07 ± 0.63 3.07 ± 0.69 1.00 ± 0.89  
Oral pain Non intervention 9 87.33 ± 15.57 83.89 ± 17.50 −3.44 ± 7.96 0.408 4.52 ± 0.71 3.94 ± 3.94 − 0.57 ± 0.69 0.351 4.24 ± 0.94 3.93 ± 0.76 − 0.31 ± 0.68 0.758 4.02 ± 0.76 3.80 ± 1.02 − 0.22 ± 0.39 0.918 2.33 ± 0.85 2.82 ± 0.61 0.49 ± 0.67 1.000
Intervention 7 95.29 ± 6.18 89.14 ± 7.69 −6.14 ± 7.82   4.88 ± 0.25 4.05 ± 0.57 − 0.83 ± 0.54   4.33 ± 0.46 4.07 ± 0.46 − 0.26 ± 0.53   4.23 ± 0.45 3.97 0.42 −0.26 ± 0.70   3.00 ± 0.42 3.40 ± 0.54 0.40 ± 0.74  
Vomiting Non intervention 5 85.60 ± 7.80 78.20 ± 10.62 −7.40 ± 7.67 0.571 4.53 ± 0.73 3.93 ± 0.80 −0.60 ± 0.91 1.000 4.40 ± 0.30 3.60 ± 0.48 − 0.80 ± 0.22 0.190 3.84 ± 0.61 3.48 ± 0.92 − 0.36 ± 0.41 0.571 2.00 ± 0.57 2.36 ± 0.46 0.36 ± 0.61 0.095
Intervention 2 93.00 ± 2.83 94.50 ± 16.26 1.50 ± 13.44   5.00 ± 0.00 4.33 ± 0.94 −0.67 ± 0.94   4.50 ± 0.71 4.08 ± 1.06 − 0.42 ± 0.35   4.40 ± 0.85 4.30 ± 0.99 − 0.10 ± 0.14   1.90 ± 1.27 3.90 ± 0.42 2.00 ± 0.85  
Fever Non intervention 4 94.50 ± 7.94 97.50 ± 7.51 3.00 ± 2.94 0.114 5.00 ± 0.00 4.92 ± 0.10 −0.08 ± 0.10 0.257 4.75 ± 0.29 4.50 ± 0.41 − 0.25 ± 0.17 0.352 4.40 ± 0.54 4.60 ± 0.43 0.20 ± 0.23 0.476 2.05 ± 0.76 2.85 ± 0.64 0.80 ± 0.67 0.476
Intervention 6 89.83 ± 14.36 87.17 ± 16.08 −2.67 ± 5.43   4.53 ± 1.00 4.03 ± 1.04 −0.50 ± 0.45   4.58 ± 0.36 4.03 ± 0.32 − 0.56 ± 0.43   3.90 ± 0.75 3.87 ± 1.19 − 0.03 ± 0.69   2.43 ± 0.78 3.07 ± 0.64 0.63 ± 0.46  
Malaise Non intervention 12 87.42 ± 11.40 79.58 ± 16.00 −7.83 ± 10.90 0.069 4.64 ± 0.64 3.78 ± 1.02 −0.86 ± 0.95 0.254 4.39 ± 0.50 3.72 ± 0.76 − 0.67 ± 0.54 0.159 4.02 ± 0.55 3.72 ± 0.82 − 0.30 ± 0.54 0.203 2.03 ± 0.85 2.53 ± 0.67 0.50 ± 0.66 0.043*
Intervention 10 86.00 ± 8.83 88.10 ± 13.88 2.10 ± 7.97   4.67 ± 0.78 4.23 ± 0.95 −0.43 ± 0.64   4.40 ± 0.55 4.07 ± 0.66 −0.33 ± 0.41   3.74 ± 0.56 3.84 ± 0.95 0.10 ± 0.63   1.86 ± 0.65 3.10 ± 0.57 1.24 ± 0.85  
Anorexia Non intervention 10 81.60 ± 11.51 73.30 ± 12.62 −8.30 ± 12.00 0.152 4.43 ± 0.79 3.48 ± 1.02 −0.95 ± 1.01 0.152 4.08 ± 0.79 3.45 ± 0.60 −0.63 ± 0.83 0.099 3.76 ± 0.59 3.36 ± 0.71 − 0.40 ± 0.52 0.099 1.80 ± 0.60 2.38 ± 0.44 0.58 ± 0.69 0.468
Intervention 11 90.64 ± 8.16 90.82 ± 9.02 0.18 ± 7.31   4.92 ± 0.16 4.47 ± 0.60 −0.45 ± 0.63   4.39 ± 0.54 4.09 ± 0.60 − 0.30 ± 0.45   3.84 ± 0.56 3.95 ± 0.51 0.11 ± 0.64   2.36 ± 0.79 3.22 ± 0.60 0.85 ± 0.82  
Peripheral sensory neuropathy Non intervention 3 80.67 ± 8.39 75.33 ± 8.74 −5.33 ± 17.01 0.571 4.33 ± 0.67 3.61 ± 0.77 −0.72 ± 1.39 0.571 4.22 ± 0.42 4.00 ± 0.83 − 0.22 ± 1.07 1.000 3.20 ± 0.53 2.73 ± 0.46 − 0.47 ± 0.58 0.571 2.07 ± 0.50 2.47 ± 0.46 0.40 ± 0.20 0.250
Intervention 5 85.60 ± 12.38 82.80 ± 14.34 −2.80 ± 6.98   4.43 ± 1.08 3.90 ± 1.07 −0.53 ± 0.40   4.43 ± 0.15 4.03 ± 0.46 −0.40 ± 0.52   3.64 ± 0.50 3.44 ± 1.03 − 0.20 ± 0.60   2.20 ± 1.01 2.88 ± 0.33 0.68 ± 1.01  
Alopecia Non intervention 17 90.06 ± 12.86 85.35 ± 17.08 −4.71 ± 10.42 0.876 4.75 ± 0.56 4.01 ± 1.01 −0.74 ± 0.81 0.616 4.38 ± 0.71 4.04 ± 0.77 −0.34 ± 0.68 0.925 4.02 ± 0.64 3.87 ± 0.86 − 0.15 ± 0.52 0.851 2.37 ± 0.95 2.84 ± 0.72 0.47 ± 0.62 0.573
Intervention 19 91.74 ± 9.92 89.26 ± 11.67 −2.47 ± 8.09   4.79 ± 0.58 4.25 ± 0.76 −0.54 ± 0.57   4.43 ± 0.51 4.11 ± 0.50 −0.32 ± 0.47   4.05 ± 0.66 3.94 ± 0.79 − 0.12 ± 0.73   2.50 ± 0.83 3.15 ± 0.64 0.65 ± 0.90  
Nail ridging Non intervention 3 93.67 ± 9.29 87.00 ± 17.06 −6.67 ± 10.02 0.629 4.89 ± 0.19 4.22 ± 0.92 −0.67 ± 1.01 0.857 4.50 ± 0.33 3.89 ± 0.67 −0.61 ± 0.35 1.000 4.13 ± 0.99 3.80 ± 1.39 − 0.33 ± 0.42 0.229 2.60 ± 1.20 3.13 ± 0.61 0.53 ± 0.61 0.400
Intervention 4 92.75 ± 9.74 92.00 ± 11.46 −0.75 ± 5.74   4.75 ± 0.29 4.13 ± 0.60 − 0.63 ± 0.44   4.42 ± 0.57 4.13 ± 0.44 − 0.29 ± 0.90   4.10 ± 0.62 4.15 0.74 0.05 ± 0.34   2.65 ± 0.77 3.50 ± 0.62 0.85 ± 0.25  
Skin disorder Non intervention 9 91.33 ± 14.26 84.56 ± 19.74 −6.78 ± 10.27 0.606 4.70 ± 0.56 3.89 ± 1.10 − 0.81 ± 0.83 0.606 4.44 ± 0.66 3.98 ± 0.89 − 0.46 ± 0.41 0.815 4.11 ± 0.71 3.80 ± 0.97 − 0.31 ± 0.53 0.743 2.44 ± 1.00 2.91 ± 0.82 0.47 ± 0.63 0.321
Intervention 8 90.00 ± 8.65 87.63 ± 9.61 −2.38 ± 10.32   4.83 ± 0.27 4.25 ± 0.70 − 0.58 ± 0.73   4.27 ± 0.59 3.98 ± 0.58 − 0.29 ± 0.60   4.00 ± 0.57 3.75 ± 0.44 − 0.25 ± 0.67   2.35 ± 0.95 3.18 ± 0.50 0.83 ± 1.05  
  1. Mann-Whitney's U-test, mean±standard deviation, * P < 0.05