Table 1 Comparison of signal values of elderly and non-elderly patients
adverse event (High Level Group Term) | elderly patients (over the age of 60) | non-elderly patients (under the age of 60) | |||||||
|---|---|---|---|---|---|---|---|---|---|
n11 | PRR | χ2 | signal value | n11 | PRR | χ2 | signal value | risk Judgment | |
Deliria (include confusion) | 84 | 16.2 | 1079.4 | 9.8 | 34 | 12.0 | 304.3 | 8.2 | |
Product use issues | 14 | 40.0 | 391.1 | 9.7 | 31 | 23.0 | 536.5 | 9.4 | |
Sleep disturbances (include subtypes) | 26 | 14.9 | 294.4 | 8.4 | 14 | 6.8 | 60.9 | 6.0 | |
Sleep disturbances | 38 | 10.8 | 309.3 | 8.1 | 24 | 6.0 | 91.0 | 6.3 | |
Glaucoma and ocular hypertension | 10 | 21.3 | 152.6 | 8.1 | 0(0.5) | 0(1.6) | 0.1(0.3) | -(−0.7) | × |
Psychiatric and behavioural symptoms NEC | 22 | 13.7 | 225.8 | 8.0 | 24 | 4.4 | 58.7 | 5.6 | |
Impulse control disorders NEC | 6 | 26.0 | 102.5 | 7.9 | 0(0.5) | 0(1.0) | 0.001(0.5) | -(−0.7) | × |
Dementia and amnestic conditions | 21 | 10.0 | 152.3 | 7.3 | 13 | 14.4 | 134.5 | 7.6 | |
Suicidal and self-injurious behaviours NEC | 19 | 10.4 | 142.0 | 7.3 | 49 | 7.3 | 250.17.5 | ||
Mental impairment disorders | 22 | 8.3 | 127.8 | 7.0 | 14 | 10.1 | 98.4 | 6.9 | |
Neurological disorders NEC | 153 | 3.6 | 294.5 | 7.0 | 103 | 3.6 | 194.7 | 6.5 | |
Neurological special senses and psychiatric investigations | 6 | 13.4 | 52.2 | 6.5 | 1 | 2.1 | 0.0007 | −6.5 | × |
Psychiatric disorders NEC | 39 | 4.0 | 83.1 | 5.8 | 50 | 6.1 | 203.1 | 7.1 | |
Respiratory disorders NEC | 51 | 2.9 | 60.8 | 5.2 | 35 | 2.7 | 36.1 | 4.6 | |
Injuries by physical agents | 7 | 6.4 | 25.6 | 5.1 | 2 | 1.2 | 0.0008 | −4.6 | × |
Personality disorders and disturbances in behavior | 5 | 7.6 | 21.3 | 5.1 | 3 | 1.9 | 0.6 | 0.1 | × |
Neurological disorders of the eye | 9 | 4.6 | 21.3 | 4.6 | 4 | 2.4 | 2.0 | 1.6 | × |
Injuries NEC | 35 | 2.6 | 33.0 | 4.5 | 17 | 2.6 | 15.4 | 3.7 | |
Changes in physical activity | 6 | 4.9 | 14.7 | 4.3 | 4 | 2.8 | 3.0 | 2.2 | |
Manic and bipolar mood disorders and disturbances | 3 | 6.7 | 9.0 | 4.1 | 2 | 1.2 | 0.02 | −3.8 | × |
Movement disorders (include parkinsonism) | 21 | 2.7 | 19.9 | 4.0 | 12 | 1.6 | 2.1 | 1.2 | × |
Anxiety disorders and symptoms | 6 | 3.7 | 9.0 | 3.5 | 7 | 2.1 | 3.0 | 1.8 | |
Therapeutic and nontherapeutic effects (exclude toxicity) | 15 | 2.6 | 12.7 | 3.5 | 16 | 3.0 | 19.1 | 4.1 | |
Enzyme investigations NEC | 17 | 2.4 | 12.4 | 3.4 | 3 | 0.4 | 2.1 | −0.2 | × |
Disturbances in thinking and perception | 12 | 2.5 | 9.1 | 3.1 | 5 | 1.2 | 0.05 | −2.9 | × |
Vision disorders | 7 | 2.6 | 5.3 | 2.6 | 3 | 1.6 | 0.2 | −0.9 | × |
Ocular infections irritations and inflammations | 8 | 2.4 | 5.0 | 2.5 | 0(0.5) | 0(0.1) | 3.7(2.9) | -(−1.2) | × |
Depressed mood disorders and disturbances | 5 | 2.8 | 4.1 | 2.4 | 6 | 2.5 | 3.9 | 2.3 | |