Skip to main content

Table 1 Comparison of signal values of elderly and non-elderly patients

From: Analyses of non-benzodiazepine-induced adverse events and prognosis in elderly patients based on the Japanese adverse drug event report database

adverse event (High Level Group Term) elderly patients (over the age of 60) non-elderly patients (under the age of 60)  
n11 PRR χ2 signal value n11 PRR χ2 signal value risk Judgment
Deliria (include confusion) 84 16.2 1079.4 9.8 34 12.0 304.3 8.2  
Product use issues 14 40.0 391.1 9.7 31 23.0 536.5 9.4  
Sleep disturbances (include subtypes) 26 14.9 294.4 8.4 14 6.8 60.9 6.0  
Sleep disturbances 38 10.8 309.3 8.1 24 6.0 91.0 6.3  
Glaucoma and ocular hypertension 10 21.3 152.6 8.1 0(0.5) 0(1.6) 0.1(0.3) -(−0.7) ×
Psychiatric and behavioural symptoms NEC 22 13.7 225.8 8.0 24 4.4 58.7 5.6  
Impulse control disorders NEC 6 26.0 102.5 7.9 0(0.5) 0(1.0) 0.001(0.5) -(−0.7) ×
Dementia and amnestic conditions 21 10.0 152.3 7.3 13 14.4 134.5 7.6  
Suicidal and self-injurious behaviours NEC 19 10.4 142.0 7.3 49 7.3 250.17.5   
Mental impairment disorders 22 8.3 127.8 7.0 14 10.1 98.4 6.9  
Neurological disorders NEC 153 3.6 294.5 7.0 103 3.6 194.7 6.5  
Neurological special senses and psychiatric investigations 6 13.4 52.2 6.5 1 2.1 0.0007 −6.5 ×
Psychiatric disorders NEC 39 4.0 83.1 5.8 50 6.1 203.1 7.1  
Respiratory disorders NEC 51 2.9 60.8 5.2 35 2.7 36.1 4.6  
Injuries by physical agents 7 6.4 25.6 5.1 2 1.2 0.0008 −4.6 ×
Personality disorders and disturbances in behavior 5 7.6 21.3 5.1 3 1.9 0.6 0.1 ×
Neurological disorders of the eye 9 4.6 21.3 4.6 4 2.4 2.0 1.6 ×
Injuries NEC 35 2.6 33.0 4.5 17 2.6 15.4 3.7  
Changes in physical activity 6 4.9 14.7 4.3 4 2.8 3.0 2.2  
Manic and bipolar mood disorders and disturbances 3 6.7 9.0 4.1 2 1.2 0.02 −3.8 ×
Movement disorders (include parkinsonism) 21 2.7 19.9 4.0 12 1.6 2.1 1.2 ×
Anxiety disorders and symptoms 6 3.7 9.0 3.5 7 2.1 3.0 1.8  
Therapeutic and nontherapeutic effects (exclude toxicity) 15 2.6 12.7 3.5 16 3.0 19.1 4.1  
Enzyme investigations NEC 17 2.4 12.4 3.4 3 0.4 2.1 −0.2 ×
Disturbances in thinking and perception 12 2.5 9.1 3.1 5 1.2 0.05 −2.9 ×
Vision disorders 7 2.6 5.3 2.6 3 1.6 0.2 −0.9 ×
Ocular infections irritations and inflammations 8 2.4 5.0 2.5 0(0.5) 0(0.1) 3.7(2.9) -(−1.2) ×
Depressed mood disorders and disturbances 5 2.8 4.1 2.4 6 2.5 3.9 2.3  
  1. ※ n 11 the number of co-occurrences of interest, PRR proportional reporting ratio, signal value: ln(PRR) + ln(χ2), risk judgment: low signal values of non-elderly patients than half of the signal value of the elderly, NEC not elsewhere classified