Table 2 Effect of food intake on the pharmacokinetic parameters of CPFX after 10 mg/kg CPFX oral administration alone, and with 13.3 mg/kg AL in rats
From: Food intake attenuates the drug interaction between new quinolones and aluminum
Diet | AL | Cmax (μg/mL) | AUC0–6 (μg∙h/mL) | ke (h− 1) |
|---|---|---|---|---|
Fasted | – | 0.92 ± 0.19 | 1.15 ± 0.24 | 0.36 ± 0.11 |
+ | 0.16 ± 0.08* | 0.20 ± 0.07* | 0.47 ± 0.37 | |
Fed | – | 0.59 ± 0.23# | 0.90 ± 0.16# | 0.25 ± 0.06 |
+ | 0.15 ± 0.07* | 0.30 ± 0.07* | 0.39 ± 0.31 |