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Table 2 Effect of food intake on the pharmacokinetic parameters of CPFX after 10 mg/kg CPFX oral administration alone, and with 13.3 mg/kg AL in rats

From: Food intake attenuates the drug interaction between new quinolones and aluminum

Diet AL Cmax (μg/mL) AUC0–6 (μg∙h/mL) ke (h− 1)
Fasted 0.92 ± 0.19 1.15 ± 0.24 0.36 ± 0.11
+ 0.16 ± 0.08* 0.20 ± 0.07* 0.47 ± 0.37
Fed 0.59 ± 0.23# 0.90 ± 0.16# 0.25 ± 0.06
+ 0.15 ± 0.07* 0.30 ± 0.07* 0.39 ± 0.31
  1. Data are mean ± SD, n = 5
  2. *p < 0.05 vs respective CPFX alone group. #p < 0.05 vs fasted CPFX group