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Table 3 Stabilities of colistin A, colistin B, and netilmicin

From: Rapid, simple, and clinically applicable high-performance liquid chromatography method for clinical determination of plasma colistin concentrations

Sample

Concentration (μg/mL)

Frozena (%)

Refrigerateda (%)

Room temperaturea (%)

Freeze-thawb (%)

Colistin A

8.00

102 ± 2

100 ± 3

99 ± 2

100 ± 2

 

0.10

105 ± 3

100 ± 1

102 ± 3

97 ± 3

Colistin B

8.00

100 ± 3

98 ± 3

101 ± 2

99 ± 3

 

0.10

105 ± 2

102 ± 2

102 ± 2

102 ± 3

Netilmicin

8.00

103 ± 3

101 ± 2

103 ± 2

102 ± 2

 

0.10

102 ± 3

104 ± 2

102 ± 3

98 ± 3

  1. aSamples were stored over 7 d
  2. bSample were frozen at −23 °C and thawed at room temperature for three cycles
  3. Data are reported as the mean ± standard deviation
  4. Frozen, − 23 °C; Refrigerated, 4 °C; Room temperature, 25 ± 1 °C