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Table 5 Effect of RFP pretreatment on the apparent permeability coefficient of LZD across the intestinal tissues

From: Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies

 

Papp (× 10−6 cm/s)

m-s

s-m

ER

Upper

Control

LZD

12.5 ± 5.6

11.6 ± 5.2

0.927

LY

8.93 ± 4.47

8.41 ± 4.14

0.942

with RFP

LZD

13.6 ± 5.5

12.1 ± 4.3

0.891

LY

9.09 ± 4.49

8.59 ± 3.24

0.944

Middle

Control

LZD

9.19 ± 2.27

9.44 ± 3.72

1.03

LY

6.60 ± 2.90

7.06 ± 3.14

1.07

with RFP

LZD

11.4 ± 3.4

10.2 ± 2.9

0.898

LY

7.32 ± 2.84

7.12 ± 2.65

0.973

Lower

Control

LZD

13.2 ± 3.0

10.3 ± 4.5

0.782

LY

8.84 ± 2.72

6.88 ± 3.77

0.778

with RFP

LZD

14.3 ± 4.0

12.0 ± 4.2

0.842

LY

8.85 ± 3.04

8.44 ± 3.89

0.953

  1. Values are mean ± SD of five to six rats
  2. m-s mucosal to serosal, s-m serosal to mucosal, ER efflux ratio, Papp apparent permeability coefficient, LY Lucifer yellow
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Journal of Pharmaceutical Health Care and Sciences

ISSN: 2055-0294

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