Fig. 1

Plasma concentration–time curves of carboplatin during the (a) first and (b) second chemotherapy cycle. The time intervals between the carboplatin infusion and the commencement of hemodialysis were 2 h in the first cycle and 1 h in the second cycle of gemcitabine plus carboplatin chemotherapy. Hemodialysis was performed for 3 h in each chemotherapy cycle. AUC: area under the concentration-time curve; HD, hemodialysis