Table 2 Pharmacokinetic parameters of carboplatin in the first and second cycle of gemcitabine plus carboplatin chemotherapy
Treatment phase | First cycle | Second cycle | ||||||
|---|---|---|---|---|---|---|---|---|
Measured AUC (mg/mL min) | Ke (h−1) | t1/2 (h) | CL (mL/min) | Measured AUC (mg/mL min) | Ke (h−1) | t1/2 (h) | CL (mL/min) | |
Pre-dialysis | 0.88 | 0.150 | 4.6 | – | 0.47 | 0.211 | 3.3 | – |
During dialysis | 0.74 | 0.281 | 2.5 | – | 0.66 | 0.300 | 2.3 | – |
Post-dialysis | 4.34 | 0.017 | 40.8 | – | 3.84 | 0.015 | 46.2 | – |
Total | 5.96 | – | – | 26.8 | 4.97 | – | – | 27.2 |