Fig. 1

Kaplan–Meier curves for the cumulative incidence of bone marrow suppression induced by S-1. The curves were analyzed using a log-rank test. The x- and y-axes represent the number of days after initiation of S-1 and the cumulative incidence of bone marrow suppression induced by S-1, respectively. Number at risk was shown below x- axis. RDI is the ratio of the actual dose intensity to the planned dose intensity. RDI, Relative dose intensity. a. Kaplan–Meier curves for the cumulative incidence of bone marrow suppression induced by S-1 in patients with RDI > 70% and RDI ≤70% (Model 1). Solid and dotted lines represent RDI > 70% and RDI ≤70%, respectively. b. Kaplan–Meier curves for the cumulative incidence of bone marrow suppression induced by S-1 in patients with RDI > 75% and RDI ≤75% (Model 2). Solid and dotted lines represent RDI > 75% and RDI ≤75%, respectively. c. Kaplan–Meier curves for the cumulative incidence of bone marrow suppression induced by S-1 in patients with RDI > 80% and RDI ≤80% (Model 3). Solid and dotted lines represent RDI > 80% and RDI ≤80%, respectively