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Table 3 Multivariate Cox proportional hazard model of bone marrow suppression induced by S-1

From: Impact of relative dose intensity on bone marrow suppression induced by S-1: retrospective observational study

Variables Model 1 (with RDIb > 70%) Model 2 (with RDIb > 75%) Model 3 (with RDIb > 80%)
HR 95% CI p value HR 95% CI p value HR 95% CI p value
Grade ≥ 2 lymphocytopeniaa 3.93 1.35–9.11 < 0.05 5.17 1.72–12.6 < 0.01 4.75 1.60–11.4 < 0.01
RDIb > 70% 1.42 0.88–2.38 0.16
RDIb > 75% 1.71 1.10–2.72 < 0.05
RDIb > 80% 1.65 1.07–2.54 < 0.05
  1. HR Hazard ratio, 95% CI 95% confidence interval, RDI relative dose intensity
  2. aGrade ≥ 2 lymphocytopenia at the initiation of S-1 treatment was assessed using Common Terminology Criteria for Adverse Events (CTCAE) version 4.0.
  3. bRDI is the ratio of the actual dose intensity to the planned dose intensity.