Table 3 Multivariate Cox proportional hazard model of bone marrow suppression induced by S-1
Variables | Model 1 (with RDIb > 70%) | Model 2 (with RDIb > 75%) | Model 3 (with RDIb > 80%) | ||||||
|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
Grade ≥ 2 lymphocytopeniaa | 3.93 | 1.35–9.11 | < 0.05 | 5.17 | 1.72–12.6 | < 0.01 | 4.75 | 1.60–11.4 | < 0.01 |
RDIb > 70% | 1.42 | 0.88–2.38 | 0.16 | – | – | – | – | – | – |
RDIb > 75% | – | – | – | 1.71 | 1.10–2.72 | < 0.05 | – | – | – |
RDIb > 80% | – | – | – | – | – | – | 1.65 | 1.07–2.54 | < 0.05 |