Table 4 Stratified analyses by acute kidney injury on pharmacokinetics of vancomycin

Acute kidney injury (+)

Number of patients

5

6

–

Vancomycin trough concentration (μg/mL)^a

26 (22.3–33.2)

12.8 (9.1–30.5)

0.20 ⁱ⁾

Vancomycin AUC₂₄ (μg/mL·h)^a

859 (393–971)

794 (486–1052)

0.86 ⁱ⁾

Vancomycin AUC₂₄/MIC ratio^a

859 (427–971)

809 (459–1409)

0.86 ⁱ⁾

Number of cases with failure to achieve a vancomycin AUC₂₄/MIC ratio ≤ 389

1

0

0.45 ⁱⁱ⁾

Acute kidney injury (−)

Number of patients

7

27

–

Vancomycin trough concentration (μg/mL)^a

15.0 (12.7–21.4)

14.6 (9.3–18.2)

0.30 ⁱ⁾

Vancomycin AUC₂₄ (μg/mL·h)^a

498 (354–765)

645 (417–853)

0.48 ⁱ⁾

Vancomycin AUC₂₄/MIC ratio^a

725 (277–1531)

707 (417–1319)

0.75 ⁱ⁾

Number of cases with failure to achieve a vancomycin AUC₂₄/MIC ratio ≤ 389

2

5

0.61 ⁱⁱ⁾