Table 1 Characteristics of patients with Clostridioides difficile infection treated with vancomycin tapered and pulsed-dose regimen
Items | n = 36 |
|---|---|
Male sex (%) | 19 (52.8) |
Age, median (IQR1) | 80.5 (21–95) |
No. of CDI episodes, mode (range) | 3 (2–7) |
Duration of treatment day, median (IQR1) | 43 (36.8–55) |
Underlying disease (%) | |
Hypertension | 12 (33.3) |
Malignancy | 10 (27.8) |
Immunocompromised | 9 (25.0) |
Diabetes mellitus | 5 (13.9) |
Prior abdominal surgery | 5 (13.9) |
Chronic kidney disease | 4 (11.1) |
Chronic liver disease | 1 (1.5) |
Charlson comorbidity index, median (range) | 2 (0–8) |
Drug use (%) | |
Proton pump inhibitors | 16 (44.4) |
Histamine receptor-2 blockers | 3 (8.3) |
Probiotics | 31 (86.1) |
Antidiarrheals | 0 (0.0) |
Antibiotic use prior 90 days | 33 (91.7) |
Disease severity (%) | |
Zar criteria [14] | |
> 2 | 5 (13.9) |
≤ 2 | 31 (86.1) |
MN criteria [15] | |
mild | 13 (36.1) |
moderate | 19 (52.8) |
severe | 3 (8.3) |