| No. | Age (Sex) | Median (IQR) | Body Weight (kg) | (kg, IQR) | 4F-PCC dose (IU/kg) | Infusion time (min) | IV Vitamin K | initial PT-INR | post-4F-PCC PT-INR | Consent form acquistion time (min) | (min, IQR) | Time from patient presentation to prescription ordering (min) | Time from prescription ordering to administration (min) | Type of injury | Reason for administration |
|---|
| A | 77(F) | 74 (70–79) | 55.5 | 55.5 (42.1–66.4) | 18.0 | 8 | + | 2.20 | 1.32 | 105 | 103 (67–121) | 105 | 5 | ASDH | Bleeding |
| B | 82(F) | 38.0 | 26.0 | 8 | + | 3.69 | 1.39 | 103 | 87 | 16 | Pelvic fracture | Bleeding |
| C | 74(M) | 46.2 | 54.1 | 12 | + | 11.98 | 1.42 | 137 | 105 | 39 | Cholecystitis | Urgent procedures |
| D | 68(F) | 73.8 | 47.4 | 17 | + | 7.94 | 1.44 | 93 | 72 | 21 | Sepsis | Urgent procedures |
| E | 72(M) | 59.0 | 25.4 | 24 | + | 3.94 | 1.37 | 41 | 17 | 24 | Liver damage | Bleeding |
| F | 89(F) | 89 (67–92) | 43.0 | 48.0 (42.5–63.0) | 23.3 | IV | + | 2.71 | 1.26 | 177 | 45 (22–128) | 46 | 157 | ASDH | Bleeding |
| G | 90(M) | 73.0 | 24.0 | 17 | + | 3.84< | 1.40 | 79 | 95 | 74 | ICH | Bleeding |
| H | 94(F) | 48.0 | 25.0 | 19 | + | 2.95 | 1.15 | 45 | 60 | 51 | Traumatic pneumothorax | Bleeding |
| I | 71(F) | 42.0 | 23.8 | 16 | + | 2.07 | 1.30 | 10 | 37 | 33 | Pelvic fracture | Bleeding |
| J | 63(M) | 53.0 | 37.7 | 32 | – | 5.02 | 1.45 | 34 | 34 | 60 | Pelvic fracture | Bleeding |
- 4F-PCC four factor prothrombin complex concentrate; A-E: Intervention group F-J: Nonintervention group
- PT-INR prothrombin time-international normalized ratio; IQR interquartile range;
- ASDH acute subdual hemorrhage; ICH intracranial hemorrhage; IV intravenous
