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Table 1 4F-PCC Administration Characteristics

From: Emergency intensive care unit pharmacist’s intervention may reduce time to four-factor prothrombin complex concentrate administration: a retrospective study

No.

Age (Sex)

Median (IQR)

Body Weight (kg)

(kg, IQR)

4F-PCC dose (IU/kg)

Infusion time (min)

IV Vitamin K

initial PT-INR

post-4F-PCC PT-INR

Consent form acquistion time (min)

(min, IQR)

Time from patient presentation to prescription ordering (min)

Time from prescription ordering to administration (min)

Type of injury

Reason for administration

A

77(F)

74 (70–79)

55.5

55.5 (42.1–66.4)

18.0

8

+

2.20

1.32

105

103 (67–121)

105

5

ASDH

Bleeding

B

82(F)

38.0

26.0

8

+

3.69

1.39

103

87

16

Pelvic fracture

Bleeding

C

74(M)

46.2

54.1

12

+

11.98

1.42

137

105

39

Cholecystitis

Urgent procedures

D

68(F)

73.8

47.4

17

+

7.94

1.44

93

72

21

Sepsis

Urgent procedures

E

72(M)

59.0

25.4

24

+

3.94

1.37

41

17

24

Liver damage

Bleeding

F

89(F)

89 (67–92)

43.0

48.0 (42.5–63.0)

23.3

IV

+

2.71

1.26

177

45 (22–128)

46

157

ASDH

Bleeding

G

90(M)

73.0

24.0

17

+

3.84<

1.40

79

95

74

ICH

Bleeding

H

94(F)

48.0

25.0

19

+

2.95

1.15

45

60

51

Traumatic pneumothorax

Bleeding

I

71(F)

42.0

23.8

16

+

2.07

1.30

10

37

33

Pelvic fracture

Bleeding

J

63(M)

53.0

37.7

32

5.02

1.45

34

34

60

Pelvic fracture

Bleeding

  1. 4F-PCC four factor prothrombin complex concentrate; A-E: Intervention group F-J: Nonintervention group
  2. PT-INR prothrombin time-international normalized ratio; IQR interquartile range;
  3. ASDH acute subdual hemorrhage; ICH intracranial hemorrhage; IV intravenous