Table 1 The remaining CDDP and pH increase in a time-dependent manner under each shading condition
From: Effect of different shielding conditions on the stability of Cisplatin
Shading condition | CDDP Conc. | Storage time (h) | |||||||
|---|---|---|---|---|---|---|---|---|---|
0 | 3 | 6 | 24 | 48 | 72 | 96 | 120 | ||
Al | 250 μg/mL | 100 ± 0.0 (3.91 ± 0.05) | 101.7 ± 1.1 (3.92 ± 0.04) | 102.5 ± 1.2 (3.89 ± 0.02) | 101.5 ± 1.4 (3.76 ± 0.11) | 101.9 ± 1.7 (3.92 ± 0.08) | 101.1 ± 1.2 (3.90 ± 0.11) | 101.5 ± 2.0 (3.91 ± 0.07) | 101.0 ± 1.0 (3.85 ± 0.07) |
100 μg/mL | 100 ± 0.0 (4.30 ± 0.06) | 101 ± 1.2 (4.31 ± 0.04) | 101.8 ± 1.8 (4.30 ± 0.01) | 100.3 ± 2.7 (4.19 ± 0.09) | 101.8 ± 1.6 (4.32 ± 0.06) | 100.8 ± 2.8 (4.31 ± 0.09) | 101.6 ± 1.5 (4.26 ± 0.12) | 100.6 ± 2.9 (4.27 ± 0.03) | |
50 μg/mL | 100 ± 0.0 (4.60 ± 0.03) | 102.2 ± 0.7 (4.61 ± 0.03) | 100.8 ± 0.3 (4.61 ± 0.02) | 102.0 ± 1.4 (4.52 ± 0.12) | 100.0 ± 0.4 (4.62 ± 0.08) | 101.2 ± 2.3 (4.59 ± 0.10) | 101.5 ± 1.2 (4.63 ± 0.05) | 100.9 ± 2.3 (4.61 ± 0.01) | |
BSC | 250 μg/mL | 100 ± 0.0 (3.91 ± 0.06) | 100.6 ± 0.5 (3.93 ± 0.04) | 100.3 ± 0.2 (3.90 ± 0.02) | 99.4 ± 2.0 (3.79 ± 0.17) | 100.2 ± 0.2 (3.91 ± 0.11) | 100 ± 0.6 (3.91 ± 0.10) | 99.8 ± 0.5 (3.92 ± 0.06) | 99.3 ± 1.4 (3.88 ± 0.07) |
100 μg/mL | 100 ± 0.0 (4.30 ± 0.05) | 101.2 ± 0.4 (4.29 ± 0.05) | 102.2 ± 0.7 (4.30 ± 0.01) | 101.1 ± 0.1 (4.18 ± 0.10) | 100.6 ± 1.2 (4.32 ± 0.08) | 101.8 ± 0.8 (4.29 ± 0.09) | 100.8 ± 0.8 (4.30 ± 0.09) | 100.8 ± 1.9 (4.32 ± 0.03) | |
50 μg/mL | 100 ± 0.0 (4.61 ± 0.04) | 99.7 ± 1.6 (4.60 ± 0.04) | 100.3 ± 1.2 (4.62 ± 0.02) | 100.4 ± 1.8 (4.51 ± 0.13) | 100.4 ± 2.6 (4.64 ± 0.07) | 101.1 ± 2.9 (4.59 ± 0.11) | 100.8 ± 1.3 (4.63 ± 0.08) | 97.5 ± 1.4 (4.65 ± 0.01) | |
YSC | 250 μg/mL | 100 ± 0.0 (3.91 ± 0.05) | 102.2 ± 1.0 (3.92 ± 0.04) | 101.0 ± 1.0 (3.91 ± 0.01) | 100.2 ± 1.9 (3.79 ± 0.16) | 100.0 ± 2.2 (3.95 ± 0.06) | 100.7 ± 1.8 (3.95 ± 0.09) | 100.2 ± 2.2 (3.92 ± 0.08) | 100.2 ± 2.9 (3.94 ± 0.06) |
100 μg/mL | 100 ± 0.0 (4.31 ± 0.04) | 101.4 ± 0.7 (4.31 ± 0.05) | 101.5 ± 0.8 (4.30 ± 0.02) | 99.7 ± 1.1 (4.20 ± 0.13) | 101.0 ± 0.4 (4.31 ± 0.09) | 100.1 ± 0.9 (4.33 ± 0.10) | 99.9 ± 0.1 (4.38 ± 0.10) | 100.9 ± 1.0 (4.36 ± 0.04) | |
50 μg/mL | 100 ± 0.0 (4.62 ± 0.03) | 99.9 ± 1.1 (4.60 ± 0.03) | 99.0 ± 1.4 (4.62 ± 0.02) | 98.6 ± 2.1 (4.51 ± 0.14) | 97.8 ± 1.1 (4.64 ± 0.06) | 98.8 ± 3.1 (4.64 ± 0.09) | 98.1 ± 2.0 (4.63 ± 0.10) | 97.6 ± 1.0 (4.66 ± 0.02) | |
MAC | 250 μg/mL | 100 ± 0.0 (3.91 ± 0.03) | 100.2 ± 0.8 (3.96 ± 0.04) | 99.3 ± 2.0 (3.95 ± 0.01) | 94.3 ± 2.0 (4.06 ± 0.19) | a88.9 ± 1.3 (4.77 ± 0.12) | a82.9 ± 1.4 (5.97 ± 0.21) | b76.0 ± 2.0 (6.50 ± 0.17) | b70.8 ± 1.3 (6.85 ± 0.09) |
100 μg/mL | 100 ± 0.0 (4.30 ± 0.03) | 100.8 ± 1.6 (4.35 ± 0.04) | 99.0 ± 1.4 (4.35 ± 0.03) | 95.0 ± 1.8 (4.52 ± 0.18) | a87.9 ± 1.8 (5.23 ± 0.08) | a83.6 ± 1.4 (6.04 ± 0.12) | b76.8 ± 2.0 (6.50 ± 0.03) | b70.0 ± 2.7 (6.77 ± 0.05) | |
50 μg/mL | 100 ± 0.0 (4.63 ± 0.02) | 100.4 ± 1.2 (4.63 ± 0.04) | 98.5 ± 0.6 (4.67 ± 0.03) | 94.6 ± 2.4 (4.77 ± 0.14) | a89.7 ± 1.8 (5.33 ± 0.09) | a83.6 ± 1.8 (5.91 ± 0.15) | b76.6 ± 4.0 (6.32 ± 0.06) | b71.5 ± 2.9 (6.54 ± 0.03) | |
NSC | 250 μg/mL | 100 ± 0.0 (3.94 ± 0.05) | 100.2 ± 2.0 (3.96 ± 0.06) | 98.6 ± 1.6 (3.96 ± 0.02) | 94.7 ± 1.2 (4.11 ± 0.21) | a85.3 ± 4.5 (4.86 ± 0.23) | a82.4 ± 1.4 (6.25 ± 0.21) | b75.0 ± 1.0 (6.84 ± 0.07) | c68.7 ± 0.4 (7.11 ± 0.11) |
100 μg/mL | 100 ± 0.0 (4.31 ± 0.02) | 99.9 ± 1.1 (4.36 ± 0.02) | 98.3 ± 1.4 (4.36 ± 0.03) | 92.6 ± 1.1 (4.53 ± 0.13) | a84.0 ± 5.7 (5.31 ± 0.12) | a81.3 ± 0.4 (6.21 ± 0.14) | b74.9 ± 1.5 (6.60 ± 0.21) | c68.9 ± 1.9 (6.83 ± 0.05) | |
50 μg/mL | 100 ± 0.0 (4.61 ± 0.06) | 102.1 ± 2.3 (4.66 ± 0.03) | 98.3 ± 1.3 (4.68 ± 0.03) | 93.8 ± 1.5 (4.79 ± 0.08) | a86.2 ± 3.8 (5.40 ± 0.11) | a83.1 ± 2.5 (6.03 ± 0.18) | b77.4 ± 0.6 (6.39 ± 0.02) | c69.2 ± 2.3 (6.63 ± 0.03) | |