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Table 1 The remaining CDDP and pH increase in a time-dependent manner under each shading condition

From: Effect of different shielding conditions on the stability of Cisplatin

Shading conditionCDDP Conc.Storage time (h)
03624487296120
Al250 μg/mL100 ± 0.0 (3.91 ± 0.05)101.7 ± 1.1 (3.92 ± 0.04)102.5 ± 1.2 (3.89 ± 0.02)101.5 ± 1.4 (3.76 ± 0.11)101.9 ± 1.7 (3.92 ± 0.08)101.1 ± 1.2 (3.90 ± 0.11)101.5 ± 2.0 (3.91 ± 0.07)101.0 ± 1.0 (3.85 ± 0.07)
100 μg/mL100 ± 0.0 (4.30 ± 0.06)101 ± 1.2 (4.31 ± 0.04)101.8 ± 1.8 (4.30 ± 0.01)100.3 ± 2.7 (4.19 ± 0.09)101.8 ± 1.6 (4.32 ± 0.06)100.8 ± 2.8 (4.31 ± 0.09)101.6 ± 1.5 (4.26 ± 0.12)100.6 ± 2.9 (4.27 ± 0.03)
50 μg/mL100 ± 0.0 (4.60 ± 0.03)102.2 ± 0.7 (4.61 ± 0.03)100.8 ± 0.3 (4.61 ± 0.02)102.0 ± 1.4 (4.52 ± 0.12)100.0 ± 0.4 (4.62 ± 0.08)101.2 ± 2.3 (4.59 ± 0.10)101.5 ± 1.2 (4.63 ± 0.05)100.9 ± 2.3 (4.61 ± 0.01)
BSC250 μg/mL100 ± 0.0 (3.91 ± 0.06)100.6 ± 0.5 (3.93 ± 0.04)100.3 ± 0.2 (3.90 ± 0.02)99.4 ± 2.0 (3.79 ± 0.17)100.2 ± 0.2 (3.91 ± 0.11)100 ± 0.6 (3.91 ± 0.10)99.8 ± 0.5 (3.92 ± 0.06)99.3 ± 1.4 (3.88 ± 0.07)
100 μg/mL100 ± 0.0 (4.30 ± 0.05)101.2 ± 0.4 (4.29 ± 0.05)102.2 ± 0.7 (4.30 ± 0.01)101.1 ± 0.1 (4.18 ± 0.10)100.6 ± 1.2 (4.32 ± 0.08)101.8 ± 0.8 (4.29 ± 0.09)100.8 ± 0.8 (4.30 ± 0.09)100.8 ± 1.9 (4.32 ± 0.03)
50 μg/mL100 ± 0.0 (4.61 ± 0.04)99.7 ± 1.6 (4.60 ± 0.04)100.3 ± 1.2 (4.62 ± 0.02)100.4 ± 1.8 (4.51 ± 0.13)100.4 ± 2.6 (4.64 ± 0.07)101.1 ± 2.9 (4.59 ± 0.11)100.8 ± 1.3 (4.63 ± 0.08)97.5 ± 1.4 (4.65 ± 0.01)
YSC250 μg/mL100 ± 0.0 (3.91 ± 0.05)102.2 ± 1.0 (3.92 ± 0.04)101.0 ± 1.0 (3.91 ± 0.01)100.2 ± 1.9 (3.79 ± 0.16)100.0 ± 2.2 (3.95 ± 0.06)100.7 ± 1.8 (3.95 ± 0.09)100.2 ± 2.2 (3.92 ± 0.08)100.2 ± 2.9 (3.94 ± 0.06)
100 μg/mL100 ± 0.0 (4.31 ± 0.04)101.4 ± 0.7 (4.31 ± 0.05)101.5 ± 0.8 (4.30 ± 0.02)99.7 ± 1.1 (4.20 ± 0.13)101.0 ± 0.4 (4.31 ± 0.09)100.1 ± 0.9 (4.33 ± 0.10)99.9 ± 0.1 (4.38 ± 0.10)100.9 ± 1.0 (4.36 ± 0.04)
50 μg/mL100 ± 0.0 (4.62 ± 0.03)99.9 ± 1.1 (4.60 ± 0.03)99.0 ± 1.4 (4.62 ± 0.02)98.6 ± 2.1 (4.51 ± 0.14)97.8 ± 1.1 (4.64 ± 0.06)98.8 ± 3.1 (4.64 ± 0.09)98.1 ± 2.0 (4.63 ± 0.10)97.6 ± 1.0 (4.66 ± 0.02)
MAC250 μg/mL100 ± 0.0 (3.91 ± 0.03)100.2 ± 0.8 (3.96 ± 0.04)99.3 ± 2.0 (3.95 ± 0.01)94.3 ± 2.0 (4.06 ± 0.19)a88.9 ± 1.3 (4.77 ± 0.12)a82.9 ± 1.4 (5.97 ± 0.21)b76.0 ± 2.0 (6.50 ± 0.17)b70.8 ± 1.3 (6.85 ± 0.09)
100 μg/mL100 ± 0.0 (4.30 ± 0.03)100.8 ± 1.6 (4.35 ± 0.04)99.0 ± 1.4 (4.35 ± 0.03)95.0 ± 1.8 (4.52 ± 0.18)a87.9 ± 1.8 (5.23 ± 0.08)a83.6 ± 1.4 (6.04 ± 0.12)b76.8 ± 2.0 (6.50 ± 0.03)b70.0 ± 2.7 (6.77 ± 0.05)
50 μg/mL100 ± 0.0 (4.63 ± 0.02)100.4 ± 1.2 (4.63 ± 0.04)98.5 ± 0.6 (4.67 ± 0.03)94.6 ± 2.4 (4.77 ± 0.14)a89.7 ± 1.8 (5.33 ± 0.09)a83.6 ± 1.8 (5.91 ± 0.15)b76.6 ± 4.0 (6.32 ± 0.06)b71.5 ± 2.9 (6.54 ± 0.03)
NSC250 μg/mL100 ± 0.0 (3.94 ± 0.05)100.2 ± 2.0 (3.96 ± 0.06)98.6 ± 1.6 (3.96 ± 0.02)94.7 ± 1.2 (4.11 ± 0.21)a85.3 ± 4.5 (4.86 ± 0.23)a82.4 ± 1.4 (6.25 ± 0.21)b75.0 ± 1.0 (6.84 ± 0.07)c68.7 ± 0.4 (7.11 ± 0.11)
100 μg/mL100 ± 0.0 (4.31 ± 0.02)99.9 ± 1.1 (4.36 ± 0.02)98.3 ± 1.4 (4.36 ± 0.03)92.6 ± 1.1 (4.53 ± 0.13)a84.0 ± 5.7 (5.31 ± 0.12)a81.3 ± 0.4 (6.21 ± 0.14)b74.9 ± 1.5 (6.60 ± 0.21)c68.9 ± 1.9 (6.83 ± 0.05)
50 μg/mL100 ± 0.0 (4.61 ± 0.06)102.1 ± 2.3 (4.66 ± 0.03)98.3 ± 1.3 (4.68 ± 0.03)93.8 ± 1.5 (4.79 ± 0.08)a86.2 ± 3.8 (5.40 ± 0.11)a83.1 ± 2.5 (6.03 ± 0.18)b77.4 ± 0.6 (6.39 ± 0.02)c69.2 ± 2.3 (6.63 ± 0.03)
  1. Data of the remaining CDDP (pH increase) represent the mean with SD of three independent samples. a < 90%, b < 80%, and c < 70% shows the remaining CDDP compared to 0 h data. Al: aluminum foil, BSC brown shading cover, YSC yellow shading cover, MAC milky-white anti-exposure cover, and NSC no shading cover