Fig. 1
From: Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital
Measured (circles) and estimated (lines) plasma concentrations of edoxaban in a patient who took an excessive single oral dose of 750 mg. The plasma concentration curve after virtual administration of 750 mg of edoxaban (solid line) is shown with the 95% confidence interval (broken lines) based on the hepatic intrinsic clearance values of 100 virtual subjects created using random numbers, as described previously [10]. The open circle at 100 h indicates that edoxaban was detectable, but below the measurable limit, using the present liquid chromatography–tandem mass spectrometry system