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Table 1 Clinical laboratory results in a patient who had taken a single oral overdose of 750 mg of edoxaban

From: Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital

  Time after administration (h) of oral dose
8 13 28 36 52 60
Activated partial thromboplastin time (s) 59.4 43.0 30.9 26.2 26.1 25.9
Prothrombin time (s) 54.8 33.7 14.9 13.4 11.5 11.5
International normalized ratio 4.34 2.69 1.21 1.09 0.94 0.94
Hemoglobin (g/dL) 12.8   12.1   11.9 12.1
Hematocrit (%) 36.2   35.2   36.4 33.4
Platelet count (per μL) 197,000   168,000   187,000 170,000
Serum creatinine (mg/dL) 0.76 0.82 0.93 0.82 0.83 0.73
Creatinine clearance (mL/min) 89 82 73 82 81 93
  1. Concomitant drugs for this subject were fluvoxamine, lorazepam, valproic acid, promethazine, quazepam, levomepromazine, sertraline, quetiapine, esomeprazole, and polycarbophil calcium, which might not substantially affect the edoxaban pharmacokinetics