Table 1 Clinical laboratory results in a patient who had taken a single oral overdose of 750 mg of edoxaban
From: Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital
Time after administration (h) of oral dose | ||||||
|---|---|---|---|---|---|---|
8 | 13 | 28 | 36 | 52 | 60 | |
Activated partial thromboplastin time (s) | 59.4 | 43.0 | 30.9 | 26.2 | 26.1 | 25.9 |
Prothrombin time (s) | 54.8 | 33.7 | 14.9 | 13.4 | 11.5 | 11.5 |
International normalized ratio | 4.34 | 2.69 | 1.21 | 1.09 | 0.94 | 0.94 |
Hemoglobin (g/dL) | 12.8 | 12.1 | 11.9 | 12.1 | ||
Hematocrit (%) | 36.2 | 35.2 | 36.4 | 33.4 | ||
Platelet count (per μL) | 197,000 | 168,000 | 187,000 | 170,000 | ||
Serum creatinine (mg/dL) | 0.76 | 0.82 | 0.93 | 0.82 | 0.83 | 0.73 |
Creatinine clearance (mL/min) | 89 | 82 | 73 | 82 | 81 | 93 |