Fig. 3
Relationship between the apparent permeation clearance (CLP,app) values and physicochemical properties of antineoplastic agents. The relationships between CLP,app of antineoplastic agents through nitrile medical gloves (0.05 mm thickness) and molecular weight (MW) [panel (a)] and logarithm of octanol-water partition coefficient (LogP) [panel (b)] are shown. Symbols and bars indicate mean and standard deviation (SD), respectively. A statistically significant negative correlation between CLP,app and MW was observed (P = 0.026, Spearman’s rank correlation coefficient). In contrast, no statistically significant correlation between CLP,app and LogP was observed (P = 0.39, Spearman’s rank correlation coefficient). Since cisplatin, doxorubicin, and oxaliplatin (indicated with an asterisk) were not detected in the receptor solution at 240 min from the start of the permeation experiments, CLP,app values of these antineoplastic agents were calculated as zero