Factors influencing the effectiveness of recombinant human soluble thrombomodulin on disseminated intravascular coagulation: a retrospective study

Table 2 Baseline clinical characteristics and laboratory data of patients

Factors	Survival	Death	p value
Factors	n = 124	n = 103	p value
Sex (Male/Female)	69/55	72/31	0.029^a
Age	77 (68.5–85.5)^e	79 (72–87)^e	0.702^b
Body weight (kg)	51.3 (45.8–60.0)^e	48 (42–59)^e	0.322^b
eGFR (mL/min/1.73 m²)	38.5 (16.4–57.3)^e	42.5 (22.9–69.1)^e	0.272^c
Proportion of patients with sepsis-induced DIC (%)	96	93	0.283^a
Proportion of patients with solid tumor-induced DIC (%)	1.5	4	0.411^a
Proportion of patients with trauma-induced DIC (%)	2.5	3	1.000^a
SIRS score	2 (1.0–3.0)^e	2 (1.0–3.0)^e	0.226^b
FDP (μg/mL)	32.5 (19.2–64.8)^e	41.6 (20.7–77.1)^e	0.137^c
PLT (×10⁴/μL)	5.6 (3.8–7.7)^e	5.5 (3.2–7.4)^e	0.688^c
PT-INR	1.26 (1.17–1.44)^e	1.44 (1.28–1.72)^e	< 0.001^c
Proportion of patients with warfarin treatment (%)	2.5	1.9	1.000^a
DIC score^d	7 (5.8–9.0)^e	7 (6.0–9.0)^e	0.365^b
rTM dose (U/kg)	351 (246–381)^e	312 (223–381)^e	0.508^b
Number of patients treated with ATIII	31	25	1.000^b
Number of patients treated in ICU	63	39	0.061^a

eGFR estimate glomerular filtration rate, SIRS systemic inflammatory response syndrome, FDP fibrinogen degradation products, PLT platelet, PT-INR prothrombin time-international normalized ratio, ATIII antithrombin III, ICU intensive care unit
^aFisher’s exact test. ^bStudent’s t-test. ^cMann–Whitney U test. ^dJAAM score. ^eEach value represents the median (25–75% percentile)

ISSN: 2055-0294