Table 3 Multivariate logistic regression analysis for risk factors of diarrhea in patients receiving naldemedine

Female

3.012

0.887–10.228

0.077

Performance status (3–4)

2.806

0.567–13.887

0.206

Opioid dose (morphine base, mg)

1.001

0.987–1.016

0.853

Naldemedine administration after more than 17 days of opioid therapy

7.539

1.446–39.305

0.016

PPI or H₂-blocker

2.323

0.476–11.334

0.297

Fentanyl

0.552

0.082–3.720

0.541

Pancreatic cancer

6.217

1.257–30.378

0.025