Fig. 2

Estimated plasma concentrations (lines) and reported/observed plasma concentrations (plots) of duloxetine (circles), flunitrazepam (triangles), quetiapine (squares), and trazodone (diamonds). Plasma concentration curves after virtual administrations (solid line) are shown with 95% confidence intervals (broken lines) based on the hepatic intrinsic clearance values shown in Table 2. Reported/observed blood levels were taken from the literature: duloxetine (60 mg, [16]), flunitrazepam (1 mg, [17]), quetiapine (25 mg, [18]), and trazodone (50 mg, [19])