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Table 3 Multiple linear regression analysis for the weight-corrected PB C/D ratio

From: Factors affecting serum phenobarbital concentration changes in pediatric patients receiving elixir and powder formulations

  α β 95% CI p-value VIF
Constant -2.026     
Body weight 0.185 0.346 0.139 - 0.533 <0.001 1.039
LDH 0.004 0.272 0.086 - 0.478 0.006 1.037
Interacting drug use
(VPA or amiodarone)
2.961 0.543 0.306 - 0.700 <0.001 1.042
  1. C/D serum concentration/dose, VPA valproic acid, PB phenobarbital, LDH lactate dehydrogenase, α partial regression coefficient, β standardized partial regression coefficient, CI confidence interval, VIF variance inflation factor
  2. Multiple linear regression analysis (forward stepwise selection method) and regression equation was found.
  3. The explanatory variables were selected according to a significant correlation with the weight-corrected PB C/D ratio using single linear regression analysis.
  4. Weight-corrected PB C/D ratio = -2.026 + 2.961 × [interacting drug use: (1=no, 2=yes)] + 0.185 × [body weight (kg)] +0.004 × [LDH (U/L)]