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Table 2 Proportion of Patients who Used PIMs by Frailty Score Level

From: Effect of number of medications and use of potentially inappropriate medications on frailty among early-stage older outpatients

PIM use

Total

n = 923

n (%)

Frailty score 0

n = 556

n (%)

Frailty score 1–2

n = 318

n (%)

Frailty score ≥ 3

n = 49

n (%)

p-valuea

Any PIM

420 (45.5)

208 (37.4)

178 (56.0)

34 (69.4)

< 0.001

PIMs

 NSAIDs

71 (7.7)

24 (4.3)

38 (11.9)

9 (18.4)

< 0.001

 Benzodiazepinesb

90 (9.8)

40 (7.2)

40 (12.6)

10 (20.4)

< 0.001

 Loop diuretics

16 (1.7)

3 (0.5)

12 (3.8)

1 (2.0)

0.004

Antithrombotic drugs

 Antiplatelet drugs including aspirin

84 (9.1)

36 (6.5)

44 (13.8)

4 (8.2)

0.007

 Combined therapy with multiple antithrombotic drugs

21 (2.3)

7 (1.3)

13 (4.1)

1 (2.0)

0.04

 Muscarinic receptor antagonists

26 (2.5)

10 (1.8)

12 (3.8)

4 (8.2)

0.006

 H2 receptor antagonists

30 (3.3)

12 (2.2)

15 (4.7)

3 (6.1)

0.02

 Sulfonylureas

39 (4.2)

17 (3.1)

18 (5.7)

4 (8.2)

0.021

 Thiazolidine derivatives

11 (1.2)

3 (0.5)

7 (2.2)

1 (2.0)

0.039

 SSRIs

12 (1.3)

4 (0.7)

6 (1.9)

2 (4.1)

0.025

  1. a Cochran-Armitage trend test
  2. b Including use as antianxiety drugs and hypnotics
  3. NSAIDs non-steroidal anti-inflammatory drugs; PIMs potentially inappropriate medications; SSRIs selective serotonin reuptake inhibitors