TY - JOUR AU - Maeshima, Tae AU - Iijima, Ryosuke AU - Watanabe, Machiko AU - Yui, Satoru AU - Itagaki, Fumio PY - 2021 DA - 2021/04/01 TI - Effect of antipsychotics on breast tumors by analysis of the Japanese Adverse Drug Event Report database and cell-based experiments JO - Journal of Pharmaceutical Health Care and Sciences SP - 13 VL - 7 IS - 1 AB - Since antipsychotics induce hyperprolactinemia via the dopamine D2 receptor, long-term administration may be a risk factor for developing breast tumors, including breast cancer. On the other hand, some antipsychotic drugs have been reported to suppress the growth of breast cancer cells in vitro. Thus, it is not clear whether the use of antipsychotics actually increases the risk of developing or exacerbating breast tumors. The purpose of this study was to clarify the effects of antipsychotic drugs on the onset and progression of breast tumors by analyzing an adverse event spontaneous reporting database and evaluating the proliferation ability of breast cancer cells. SN - 2055-0294 UR - https://doi.org/10.1186/s40780-021-00199-7 DO - 10.1186/s40780-021-00199-7 ID - Maeshima2021 ER -