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Table 2 Signal scores for antipsychotics-associated “Benign and malignant breast neoplasms”

From: Effect of antipsychotics on breast tumors by analysis of the Japanese Adverse Drug Event Report database and cell-based experiments

  total a) Benign and malignant breast neoplasms
n ROR (95%CI) PRR (X2) IC (95%CI)
Typical antipsychotic
  Haloperidol 939 1 0.49 (0.07, 3.51) 0.49 (0.13) −0.60 (−5.30, 4.11)
Bromperidol 113 1 4.14 (0.58, 29.68) 4.11 (0.27) 0.58 (−4.06, 5.43)
Pipamperone 15 0
Spiperone 0 0
Timiperone 9 0
Propericiazine 85 0
Prochlorperazine 143 0
Perphenazine 17 0
Fluphenazine 89 0
Levomepromazine 730 0
Chlorpromazine 431 0
Sulpiride 1395 12 4.05 (2.29, 7.16)* 4.02 (24.15)* 1.70 (−0.16, 3.56)
Sultopride 52 0
Nemonapride 9 0
  Pimozide 39 0
Atypical antipsychotic
  Perospirone 416 0
Risperidone 2629 11 1.95 (1.08, 3.54)* 1.95 (4.17) 0.84 (−1.08, 2.78)
Paliperidone 774 2 2.37 (0.59, 9.53) 2.37 (0.51) 0.70 (−3.16, 4.55)
Blonanserin 550 4 3.4 (1.27, 9.11)* 3.39 (4.54)* 1.19 (−1.80, 4.19)
Olanzapine 1825 2 0.51 (0.07, 3.51) 0.5 (0.52) −0.72 (−4.56, 3.13)
Quetiapine 1836 0  
Clozapine 1283 11 4.03 (2.22, 7.31)* 4.01 (21.77)* 1.67 (−0.26, 3.61)
Asenapine 134 0
Aripiprazole 2316 6 1.36 (0.61, 3.03) 1.36 (0.26) 0.37 (−2.15, 2.89)
Brexpiprazole 112 0
Zotepine 279 5 8.48 (3.50, 20.58)* 8.35 (25.39)* 1.94 (−0.84, 4.65)
Mosapramine 4 0
Oxypertine 6 0
Clocapramine 0 0
  1. ROR: the reporting odds ratio, PRR: the proportional reporting ratio, IC: the information component, CI: the confidence interval
  2. a) total number of reports from April 2004 to April 2019 in JADER
  3. An asterisk(*) indicates that the adverse events are detected as signals