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Table 2 Signal scores for antipsychotics-associated “Benign and malignant breast neoplasms”

From: Effect of antipsychotics on breast tumors by analysis of the Japanese Adverse Drug Event Report database and cell-based experiments

 

total a)

Benign and malignant breast neoplasms

n

ROR (95%CI)

PRR (X2)

IC (95%CI)

Typical antipsychotic

 

Haloperidol

939

1

0.49 (0.07, 3.51)

0.49 (0.13)

−0.60 (−5.30, 4.11)

Bromperidol

113

1

4.14 (0.58, 29.68)

4.11 (0.27)

0.58 (−4.06, 5.43)

Pipamperone

15

0

Spiperone

0

0

Timiperone

9

0

Propericiazine

85

0

Prochlorperazine

143

0

Perphenazine

17

0

Fluphenazine

89

0

Levomepromazine

730

0

Chlorpromazine

431

0

Sulpiride

1395

12

4.05 (2.29, 7.16)*

4.02 (24.15)*

1.70 (−0.16, 3.56)

Sultopride

52

0

Nemonapride

9

0

 

Pimozide

39

0

Atypical antipsychotic

 

Perospirone

416

0

Risperidone

2629

11

1.95 (1.08, 3.54)*

1.95 (4.17)

0.84 (−1.08, 2.78)

Paliperidone

774

2

2.37 (0.59, 9.53)

2.37 (0.51)

0.70 (−3.16, 4.55)

Blonanserin

550

4

3.4 (1.27, 9.11)*

3.39 (4.54)*

1.19 (−1.80, 4.19)

Olanzapine

1825

2

0.51 (0.07, 3.51)

0.5 (0.52)

−0.72 (−4.56, 3.13)

Quetiapine

1836

0

 

Clozapine

1283

11

4.03 (2.22, 7.31)*

4.01 (21.77)*

1.67 (−0.26, 3.61)

Asenapine

134

0

Aripiprazole

2316

6

1.36 (0.61, 3.03)

1.36 (0.26)

0.37 (−2.15, 2.89)

Brexpiprazole

112

0

Zotepine

279

5

8.48 (3.50, 20.58)*

8.35 (25.39)*

1.94 (−0.84, 4.65)

Mosapramine

4

0

Oxypertine

6

0

Clocapramine

0

0

  1. ROR: the reporting odds ratio, PRR: the proportional reporting ratio, IC: the information component, CI: the confidence interval
  2. a) total number of reports from April 2004 to April 2019 in JADER
  3. An asterisk(*) indicates that the adverse events are detected as signals