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Table 3 Signal scores for antipsychotics-associated “Hyperprolactinemia”

From: Effect of antipsychotics on breast tumors by analysis of the Japanese Adverse Drug Event Report database and cell-based experiments

 

total a)

Hyperprolactinemia

n

ROR (95%CI)

PRR (X2)

IC (95%CI)

Typical antipsychotic

 

Haloperidol

939

3

81.79 (25.76, 259.68)*

80.89 (158.65)*

1.95 (−1.47, 5.36)

Bromperidol

113

0

Pipamperone

15

0

Spiperone

0

0

Timiperone

9

0

Propericiazine

85

0

Prochlorperazine

143

0

Perphenazine

17

0

Fluphenazine

89

4

149.56 (54.48, 410.63)*

146.59 (424.31)*

2.28 (−0.80, 5.36)

Levomepromazine

730

0

Chlorpromazine

431

0

Sulpiride

1395

13

283.29 (156.78, 511.89)*

273.74 (2840.96)*

3.73 (1.81, 5.65)*

Sultopride

52

0

Nemonapride

9

0

 

Pimozide

39

0

Atypical antipsychotic

 

Perospirone

416

0

  

Risperidone

2629

13

190.01 (105.46–342.34)*

185.67 (1919.94)*

3.69 (1.78, 5.61)*

Paliperidone

774

23

1187.33 (728.48,1935.18)*

1050.90 (17,778.71)*

4.54 (2.96, 6.12)*

Blonanserin

550

5

184.22 (74.16, 457.61)*

179.78 (683.21)*

2.54 (−0.29, 5.37)

Olanzapine

1825

4

60.79 (22.27, 165.95)*

60.30 (170.62)*

2.22 (−0.83, 5.28)

Quetiapine

1836

1

15.24 (2.12,109.53)*

15.21 (2.84)

0.91 (−3.85, 5.66)

Clozapine

1283

0

Asenapine

134

2

188.96 (45.76, 780.12)*

184.14 (200.09)

1.57 (−2.39, 5.53)

Aripiprazole

2316

0

Brexpiprazole

112

0

Zotepine

279

0

Mosapramine

4

0

Oxypertine

6

0

Clocapramine

0

0

  1. ROR: the reporting odds ratio, PRR: the proportional reporting ratio, IC: the information component, CI: the confidence interval
  2. a) total number of reports from April 2004 to April 2019 in JADER
  3. An asterisk(*) indicates that the adverse events are detected as signals