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Table 3 Signal scores for antipsychotics-associated “Hyperprolactinemia”

From: Effect of antipsychotics on breast tumors by analysis of the Japanese Adverse Drug Event Report database and cell-based experiments

  total a) Hyperprolactinemia
n ROR (95%CI) PRR (X2) IC (95%CI)
Typical antipsychotic
  Haloperidol 939 3 81.79 (25.76, 259.68)* 80.89 (158.65)* 1.95 (−1.47, 5.36)
Bromperidol 113 0
Pipamperone 15 0
Spiperone 0 0
Timiperone 9 0
Propericiazine 85 0
Prochlorperazine 143 0
Perphenazine 17 0
Fluphenazine 89 4 149.56 (54.48, 410.63)* 146.59 (424.31)* 2.28 (−0.80, 5.36)
Levomepromazine 730 0
Chlorpromazine 431 0
Sulpiride 1395 13 283.29 (156.78, 511.89)* 273.74 (2840.96)* 3.73 (1.81, 5.65)*
Sultopride 52 0
Nemonapride 9 0
  Pimozide 39 0
Atypical antipsychotic
  Perospirone 416 0   
Risperidone 2629 13 190.01 (105.46–342.34)* 185.67 (1919.94)* 3.69 (1.78, 5.61)*
Paliperidone 774 23 1187.33 (728.48,1935.18)* 1050.90 (17,778.71)* 4.54 (2.96, 6.12)*
Blonanserin 550 5 184.22 (74.16, 457.61)* 179.78 (683.21)* 2.54 (−0.29, 5.37)
Olanzapine 1825 4 60.79 (22.27, 165.95)* 60.30 (170.62)* 2.22 (−0.83, 5.28)
Quetiapine 1836 1 15.24 (2.12,109.53)* 15.21 (2.84) 0.91 (−3.85, 5.66)
Clozapine 1283 0
Asenapine 134 2 188.96 (45.76, 780.12)* 184.14 (200.09) 1.57 (−2.39, 5.53)
Aripiprazole 2316 0
Brexpiprazole 112 0
Zotepine 279 0
Mosapramine 4 0
Oxypertine 6 0
Clocapramine 0 0
  1. ROR: the reporting odds ratio, PRR: the proportional reporting ratio, IC: the information component, CI: the confidence interval
  2. a) total number of reports from April 2004 to April 2019 in JADER
  3. An asterisk(*) indicates that the adverse events are detected as signals