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Table 5 Factors determining the occurrence of DRPs among neonates with sepsis

From: Drug-related problems and its determinant among hospitalized neonates with sepsis at Jimma University Medical Center, Ethiopia: a prospective observational study

Variables Drug-related problem identified COR[95%CI] p-value AOR[95%CI] p-value
Yes (n = 98) No (n = 103)
Age of the neonate in days (M ± SD) 14.6 ± 17.2 11.0 ± 15.3 0.9 [0.9–1.0] 0.12 1.0 [0.9–1.0] 0.80
Birth weight (kg) (M ± SD) 2.6 ± 0.7 2.8 ± 0.6 1.3 [0.8–2.0] 0.19 0.7 [0.4–1.2] 0.29
On admission vomiting Yes 30 (30.6) 16 (15.5) 0.4 [0.2–0.8] 0.01 2.2 [0.98–4.9] 0.05
No 68 (69.4) 87 (84.5) 1   1  
Hemoglobin (M ± SD) 13.7 ± 3.9 14.6 ± 3.5 1.0 [0.9–1.1] 0.09   
Oxygen saturation on admission (%) 79.1 ± 10.8 81.7 ± 11.7 1.0 [0.9–1.0] 0.11 0.9 [0.9–1.0] 0.25
Type of sepsis EONS 55 (56.1%) 67 (65.0%) 1.4 [0.8–2.5] 0.19 0.8 [0.3–2.3] 0.79
LONS 43 (43.9%) 36 (35.0%) 1   1  
Neonates taking antibiotics plus other medications Yes 53 (54.1%) 40 (38.8%) 0.5 [0.3–0.9] 0.03 5.2 [1.2–22.0] 0.02
No 45 (45.9%) 63 (61.2%) 1   1  
Number of medications taking during hospital stay (M ± SD) 2.6 ± 0.6 2.5 ± 0.7 0.7 [0.5–1.1] 0.21 0.4 [0.1–1.2] 0.11
Discharge status Alive/discharged 71 (72.4) 85 (82.5) 1.7 [0.9–3.5] 0.08 0.5 [0.2–1.0] 0.06
Death 27 (27.6) 18 (17.5) 1   1  
  1. M mean, SD standard deviation, EONS Early Onset Neonatal Sepsis, LONS Late Onset Neonatal Sepsis