Table 3 PK parameters of DGX after it was orally administered alone or coadministered with CAM after CPT-11 treatment

 DGX alone

6.43 ± 2.75

14.4 ± 3.34

4.09 ± 0.75

2.55 ± 0.80

66.1 ± 11.1

0.187 ± 0.053

 DGX + CAM

19.1 ± 6.39^*

22.8 ± 7.73

2.55 ± 0.32^*

0.885 ± 0.35^*

92.3 ± 11.4^*

0.224 ± 0.067

 DGX alone

3.40 ± 2.24

11.3 ± 2.84

5.50 ± 1.44

3.45 ± 1.27

40.8 ± 16.7^*

0.166 ± 0.030

 DGX + CAM

5.03 ± 2.86^#

13.1 ± 3.27

4.95 ± 1.68^#

2.79 ± 1.42^#

42.9 ± 15.7^#

0.155 ± 0.054