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Table 3 PK parameters of DGX after it was orally administered alone or coadministered with CAM after CPT-11 treatment

From: Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage

  Cmax AUCpo MRTpo MAT BA kepo
(ng/mL) (hr・ng/mL) (hr) (hr) (%) (1/h)
Control
 DGX alone 6.43 ± 2.75 14.4 ± 3.34 4.09 ± 0.75 2.55 ± 0.80 66.1 ± 11.1 0.187 ± 0.053
 DGX + CAM 19.1 ± 6.39* 22.8 ± 7.73 2.55 ± 0.32* 0.885 ± 0.35* 92.3 ± 11.4* 0.224 ± 0.067
CPT-11
 DGX alone 3.40 ± 2.24 11.3 ± 2.84 5.50 ± 1.44 3.45 ± 1.27 40.8 ± 16.7* 0.166 ± 0.030
 DGX + CAM 5.03 ± 2.86# 13.1 ± 3.27 4.95 ± 1.68# 2.79 ± 1.42# 42.9 ± 15.7# 0.155 ± 0.054
  1. Data are shown as the mean ± SD. (n = 7); *p < 0.05 vs. DGX alone in the control group; #p < 0.05 vs. DGX + CAM in the control group