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Table 4 PK parameters of DGX after it was intravenously administered alone or coadministered with oral CAM after CPT-11 treatment

From: Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage

  AUCiv Vdiv ke, iv CLiv
(hr・ng/mL) (L/g) (1/h) (mL/hr)
Control
 DGX alone 16.9 ± 3.88 410 ± 98.4 0.181 ± 0.070 533 ± 109
 DGX + CAM 19.5 ± 5.34 432 ± 113 0.235 ± 0.065 483 ± 110
CPT-11
 DGX alone 22.2 ± 4.59 517 ± 127 0.186 ± 0.043 361 ± 82.6*
 DGX + CAM 23.9 ± 5.55 553 ± 177 0.162 ± 0.051 329 ± 71.4
  1. Data are shown as the mean ± SD. (n = 7); *p < 0.05 vs. DGX alone in the control group