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Table 4 PK parameters of DGX after it was intravenously administered alone or coadministered with oral CAM after CPT-11 treatment

From: Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage

 

AUCiv

Vdiv

ke, iv

CLiv

(hr・ng/mL)

(L/g)

(1/h)

(mL/hr)

Control

 DGX alone

16.9 ± 3.88

410 ± 98.4

0.181 ± 0.070

533 ± 109

 DGX + CAM

19.5 ± 5.34

432 ± 113

0.235 ± 0.065

483 ± 110

CPT-11

 DGX alone

22.2 ± 4.59

517 ± 127

0.186 ± 0.043

361 ± 82.6*

 DGX + CAM

23.9 ± 5.55

553 ± 177

0.162 ± 0.051

329 ± 71.4

  1. Data are shown as the mean ± SD. (n = 7); *p < 0.05 vs. DGX alone in the control group