Table 1 Aspirin chemoprevention for colorectal tumor recurrence in a male nonsmoker subset of the Japanese J-CAPP cohort genotyped for CYP2A6*1, *4, *7, and *9
No change | Recurrence of polyps | Total | Odds ratio (95% CI) | P value | |
|---|---|---|---|---|---|
CYP2A6*1/*1,*7,*9 (normal genotypes) | |||||
Placebo | 2 | 3 | 5 | 2.2 (0.24–24) | P = 0.58 with Fisher’s exact test |
Aspirin | 3 | 10 | 13 | ||
CYP2A6*1/*4 and *4,*7,*9/*4,*7,*9 (impaired genotypes) | |||||
Placebo | 1 | 8 | 9 | 0.06 (0.005–0.76) | P < 0.05 with Fisher’s exact test |
Aspirin | 6 | 3 | 9 | ||