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Table 1 Aspirin chemoprevention for colorectal tumor recurrence in a male nonsmoker subset of the Japanese J-CAPP cohort genotyped for CYP2A6*1, *4, *7, and *9

From: Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: insights into future personalized treatments

  No change Recurrence of polyps Total Odds ratio
(95% CI)
P value
CYP2A6*1/*1,*7,*9 (normal genotypes)
 Placebo 2 3 5 2.2 (0.24–24) P = 0.58 with Fisher’s exact test
 Aspirin 3 10 13
CYP2A6*1/*4 and *4,*7,*9/*4,*7,*9 (impaired genotypes)
 Placebo 1 8 9 0.06 (0.005–0.76) P < 0.05 with Fisher’s exact test
 Aspirin 6 3 9
  1. Odds ratios are shown with respect to the reference (placebo) group. P for interaction was 0.043 (adjusted for age)