Fig. 2

Impact of osmolality of orally administered solutions on luminal concentration and fraction absorbed of atenolol in rats. A The remaining fraction of water, (B) luminal concentration of atenolol and (C) fraction absorbed of atenolol in jejunum, ileum and colon after administration of atenolol (10 μM) in purified water and hyperosmotic solution (10% NaCl) were determined by means of the in situ closed loop method for 30 min at 37 °C. The statistical significance between the different conditions was evaluated using an unpaired Student t-test. *P < 0.05, **P < 0.01, significantly different from purified water. Data are shown as means ± SEM (n = 6–9)