Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation

Table 1 Pharmacokinetic parameters of atenolol after oral administration in rats

Pharmacokinetic parameters ^a		Purified Water	Hyperosmotic Solution (10% NaCl)
Pharmacokinetic parameters ^a		(n = 6)	(n = 6)
AUC_0–7	(ng·h/mL)	212 ± 11	89.0 ± 25.4^**
AUC_0-∞	(ng·h/mL)	231 ± 11	92.9 ± 27.6^**
C_max	(ng/mL)	68.4 ± 4.7	37.6 ± 9.2^*
t_max	(h)	2.30 ± 0.30	1.92 ± 0.08
t_1/2	(h)	1.59 ± 0.15	1.38 ± 0.41

Atenolol (1 mg/kg, 0.25 mg/mL) was orally administered with purified water or hyperosmotic solution (10% NaCl)
^a AUC area under plasma concentration-time curve; C_max maximum plasma concentration; t_max time to reach maximum plasma concentration; t_1/2 elimination half-life
The statistical significance between the different conditions was evaluated using an unpaired Student t-test. *P < 0.05, **P < 0.01, significantly different from control values. Data are shown as means ± S.E. (n = 6)

ISSN: 2055-0294