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Table 1 Compounded clonidine stability

From: Stability of clonidine hydrochloride in an oral powder form compounded for pediatric patients in Japan

Study methods Storage conditions Storage container Test periods (days)
0 30 60 90 120
Bottle (closed) 25 °C ± 2 °C/60% ± 5%RH Amber/PC bottle 100.0% 99.2 ± 1.0% 98.8 ± 3.0% 99.1 ± 1.4% 99.3 ± 2.7%
Bottle (in use) Amber/PC bottle 100.0% 98.9 ± 0.9% 101.0 ± 3.0% 99.7 ± 0.7% 98.6 ± 3.1%
Laminated paper Amber/CP laminated paper 100.0% 99.9 ± 1.2% 99.4 ± 2.8% 101.9 ± 2.5% 99.2 ± 1.7%
  1. PC polycarbonate, CP cellophane and polyethylene. Clonidine concentrations are presented as percentages of the day 0 content (100.0%)