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Table 2 Clinical laboratory results in two patients who had taken single oral overdoses of diphenhydramine

From: Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital

 

Time after administration of oral dose

Case 1

Case 2

2.5 h

11.5 h

3 h

18 h

Aspartate aminotransferase (U/L)

20

26

21

19

Alanine aminotransferase (U/L)

10

11

26

22

Total bilirubin (mg/dL)

1.6

1.5

0.5

0.6

Serum creatinine (mg/dL)

0.67

0.70

0.83

0.79

Creatinine clearance (mL/min)

109

104

108

113