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Table 3 Observed plasma concentrations and PBPK modeled concentrations of diphenhydramine in two patients who had taken overdoses

From: Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital

Pharmacokinetic data Observed PBPK output a
Case 1, 900 mg diphenhydramine
 C2.5, ng/mL 977 1730 (1.8)
 C11.5, ng/mL 425 310 (0.73)
 AUC0–11.5, ng h/mL 7530 10,900 (1.5)
Case 2, 1200 mg diphenhydramine
 C3, ng/mL 1320 2110 (1.6)
 C18, ng/mL 475 220 (0.46)
 AUC0–18, ng h/mL 15,400 16,400 (1.1)
  1. aValues in parentheses are ratios of the calculated values to the observed values after 900 mg (case 1) and 1200 mg (case 2) administrations