Pharmacokinetic data | Observed | PBPK output a |
---|---|---|
Case 1, 900 mg diphenhydramine | ||
C2.5, ng/mL | 977 | 1730 (1.8) |
C11.5, ng/mL | 425 | 310 (0.73) |
AUC0–11.5, ng h/mL | 7530 | 10,900 (1.5) |
Case 2, 1200 mg diphenhydramine | ||
C3, ng/mL | 1320 | 2110 (1.6) |
C18, ng/mL | 475 | 220 (0.46) |
AUC0–18, ng h/mL | 15,400 | 16,400 (1.1) |