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Table 3 Observed plasma concentrations and PBPK modeled concentrations of diphenhydramine in two patients who had taken overdoses

From: Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital

Pharmacokinetic data

Observed

PBPK output a

Case 1, 900 mg diphenhydramine

 C2.5, ng/mL

977

1730 (1.8)

 C11.5, ng/mL

425

310 (0.73)

 AUC0–11.5, ng h/mL

7530

10,900 (1.5)

Case 2, 1200 mg diphenhydramine

 C3, ng/mL

1320

2110 (1.6)

 C18, ng/mL

475

220 (0.46)

 AUC0–18, ng h/mL

15,400

16,400 (1.1)

  1. aValues in parentheses are ratios of the calculated values to the observed values after 900 mg (case 1) and 1200 mg (case 2) administrations