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Fig. 1 | Journal of Pharmaceutical Health Care and Sciences

Fig. 1

From: Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital

Fig. 1

Measured (plots) and estimated (lines) plasma concentrations of loxoprofen and its reduced trans-alcohol metabolite: measured values were from the literature (A) and from the patient who took a single oral overdose (B). Plasma concentrations of loxoprofen (circles) and its reduced metabolite (triangles) were taken from the literature for 24 volunteers who were administered a therapeutic dose of 60 mg [4, 14] (A). Plasma concentrations of loxoprofen are also shown for the patient who took a single oral overdose of 6000 mg (B). The PBPK-modeled plasma concentration curves for loxoprofen (solid lines) and its reduced trans-alcohol metabolite (broken lines) after virtual administration of loxoprofen are also shown

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