Variables | Base case | Range | Distibution | Reference |
---|---|---|---|---|
Preemptive skin treatment cost | 5324 JPY (48.8 USD) | 50% | Gammma | 11, 14, 15, 16, 17, 18 |
Treatment cost for skin-toxicity | 16,460 JPY (151.0 USD) | 50% | Gammma | 11, 14, 15, 16, 17, 18 |
Treatment cost for severe skin-toxicity | 20,520 JPY (188.3 USD) | 50% | Gammma | 11, 14, 15, 16, 17, 18 |
Rate of severe skin-toxicity (Preemptive) | 0.023 | 50% | Beta | 11 |
Rate of severe skin-toxicity (reactive) | 0.114 | 50% | Beta | 11 |
Duration of skin treatment in post-progression state | 41 days | 95%CI | Normal | MHLW application for approval |
Utility for Progression-free survival state | 0.680 | 30% | Beta | 20 |
Utility for Post-progression survival state | 0.730 | 30% | Beta | 20 |
Disutility for skin-toxicity | 0.033 | 50% | Beta | 21, 22, 23, 24 |
Disutility for severe skin-toxicity | 0.100 | 50% | Beta | 21, 22, 23, 24 |
Discount rate | 0.02 | 0–0.04 |  | 27 |