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Table 2 Relationship between the CyA ratio and various factors

From: Analysis of the variable factors affecting changes in the blood concentration of cyclosporine before and after transfusion of red blood cell concentrate

 

All cases

Cases in which the CyA dose was not changed between before and after RCC transfusion

no.

ρ or η

P

no.

ρ or η

P

Sexa

580

0.011

0.784

252

0.053

0.402

Age

580

−0.057

0.173

252

−0.027

0.672

Body weight

563

−0.022

0.597

242

0.000

0.997

Units of RCC transfusion

580

0.026

0.534

252

0.056

0.372

HCTb

574

−0.056

0.184

251

−0.026

0.681

HCTa

571

0.187

< 0.001b

245

0.240

< 0.001b

HCT ratio

565

0.234

< 0.001b

244

0.273

< 0.001b

WBCb

475

0.123

< 0.01b

215

0.110

0.108

WBCa

500

0.091

0.041b

214

0.105

0.125

WBC ratio

447

−0.002

0.970

198

0.007

0.917

ASTb

569

0.073

0.084

247

0.129

0.042b

ASTa

567

0.120

< 0.01b

242

0.161

0.012b

ΔAST

558

0.064

0.128

239

0.144

0.026b

ALTb

569

0.049

0.245

247

0.081

0.202

ALTa

567

0.080

0.057

242

0.142

0.027b

ΔALT

558

0.095

0.025b

239

0.176

< 0.01b

ALPb

539

0.048

0.268

232

0.090

0.174

ALPa

529

0.064

0.141

224

0.118

0.079

ΔALP

508

0.102

0.021b

216

0.146

0.032b

Tbil b

561

−0.050

0.237

246

−0.027

0.675

Tbil a

563

−0.041

0.330

242

0.043

0.507

ΔTbil

548

0.048

0.259

238

0.135

0.037b

Alb b

443

−0.055

0.250

184

−0.143

0.052

Alb a

447

0.058

0.224

182

0.036

0.626

ΔAlb

356

0.228

< 0.001b

139

0.376

< 0.001b

Concomitant medicationa:

 No concomitant medication affecting Ca

541

0.134

0.015b

241

0.059

0.834

 Concomitant medication that could elevate Cac

25

5

 Concomitant medication that could lower Cad

8

5

 Concomitant medication that could elevate or lower Cae

6

1

  1. RCC red blood cell concentrate, HCT hematocrit, WBC white blood cell count, AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, Tbil total bilirubin, Alb serum albumin, CyA cyclosporine, b before RCC transfusion, a after RCC transfusion, Ca blood concentration of cyclosporine after RCC transfusion. aCorrelation ratio (η) was calculated. bP < 0.05; cInitiation of azole antifungal agent, amlodipine, nifedipine, or metronidazole. dInitiation of deferasirox, discontinuation of voriconazole, amlodipine or metronidazole, or switch from voriconazole to fluconazole. eSwitch from itraconazole to voriconazole, switch from amlodipine to nifedipine, initiation of itraconazole and deferasirox, administration or discontinuation of azole antifungal agent only for 1 or 2 days