Table 1 Antipsychotic drug concentrations in serum and breast milk samples
Drugs | Sample types | Postpartum days | Time after dose (hr) | Dose (mg) | Concentration(ng/mL) |
|---|---|---|---|---|---|
Brotizolam | Cord blood | 0 | 19.1 | 0.25 | 0.1 |
Mother serum | 0 | 33.0 | 0.25 | Below LOD | |
Mother serum | 5 | 7.5 | 0.25 | 5.0 | |
Mother serum | 17 | 19.5 | 0.25 | 0.3 | |
Breast milk | 9 | 7.5 | 0.25 | Below LOD | |
Breast milk | 9 | 11.5 | 0.25 | Below LOD | |
Periciazine | Cord blood | 0 | 19.1 | 10 | Below LOD |
Mother serum | 0 | 33.0 | 10 | Below LOD | |
Mother serum | 5 | 7.5 | 10 | 6.1 | |
Mother serum | 17 | 19.5 | 10 | Below LOD | |
Breast milk | 9 | 7.5 | 10 | 0.3 | |
Breast milk | 9 | 11.5 | 10 | 0.1 | |
Sulpiride | Cord blood | 0 | 19.1 | 100 | 122.1 |
Mother serum | 0 | 33.0 | 100 | 63.9 | |
Mother serum | 5 | 7.5 | 100 | 366.0 | |
Mother serum | 17 | 19.5 | 100 | 198.5 | |
Breast milk | 9 | 7.5 | 100 | 445.8 | |
Breast milk | 9 | 11.5 | 100 | 129.2 | |
Alprazolam | Cord blood | 0 | – | 0 | Pre-dose |
Mother serum | 0 | – | 0 | Pre-dose | |
Mother serum | 5 | 7.5 | 0.4 | 2.3 | |
Mother serum | 17 | 19.5 | 0.4 | 1.0 | |
Breast milk | 9 | 7.5 | 0.4 | 0.9 | |
Breast milk | 9 | 11.5 | 0.4 | 0.5 |