Plasma and synovial fluid concentrations of linezolid in patients with knee osteoarthritis infected with Staphylococcus aureus

Table 1 Plasma and synovial fluid concentrations of linezolid determined in two patients during knee surgery

Case (body weight)		Sampling	Linezolid concentration (μg/mL)		Ratio of synovial fluid/plasma
Case (body weight)		Sampling	Plasma	Synovial fluid	Ratio of synovial fluid/plasma
1	69-year-old woman (50 kg)	Day 5	19.6 ± 0.9	14.9 ± 0.4	76%
2	73-year-old woman (50 kg)	Day 2	15.6 ± 0.2	17.0 ± 0.5	109%

Data are means ± standard deviations from triplicate determinations
The linezolid levels in plasma and synovial fluid samples from the two patients (Fig. 1) were quantified using liquid chromatography

ISSN: 2055-0294