Ustekinumab during pregnancy and lactation: drug levels in maternal serum, cord blood, breast milk, and infant serum

Table 1 Ustekinumab concentrations in the maternal serum, cord blood, infant serum, and breast milk

Gestational weeks	Postpartum Days	Ustekinumab injection	Ustekinumab concentration (ng/mL)
Gestational weeks	Postpartum Days	Ustekinumab injection	Maternal serum	Cord blood	Infant serum	Breast milk
−3	− 289	90 mg subcutaneous
5	− 233	90 mg subcutaneous
17	− 149	90 mg subcutaneous
29	−65	90 mg subcutaneous
30	−54		7968.5
35	−19		1359.7
38	0			1131.2
	1		459.6
	5		426.3		299.0
	7		395.8
	9		373.8
	12		343.9
	13		342.4
	14		306.4
	15		291.6
	17		280.5
	19		234.8
	21		223.5
	48.2	90 mg subcutaneous				< LLOD
	48.3		106.1
	48.5					< LLOD
	49					1.5
	57					13.6
	64					10.8
	71					7.9
	77		2834.1
	78					3.4
	105		1383.7

ISSN: 2055-0294