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Table 2 Number of patients with nephrotoxicity and hematological toxicity following CDDP and 5-FU administration

From: Concomitant palonosetron ameliorates cisplatin-induced nephrotoxicity, nausea, and vomiting: a retrospective cohort study and pharmacovigilance analysis

 

Ramosetron

(n = 44)

Palonosetron

(n = 66)

p-Value

Nephrotoxicity (n = 28)

16 (36)

12 (18)

0.044

 Grade 1

12 (27)

11 (17)

 

 Grade 2

3 (7)

1 (2)

 

 Grade 3

1 (2)

0 (0)

 

Hematological toxicity (n = 45)

16 (36)

29 (44)

0.553

 Anemia

1 (2)

1 (2)

 

 Leukopenia

16 (36)

29 (44)

 

 Thrombocytopenia

1 (2)

1 (2)

 

 Neutropenia

2 (5)

3 (5)

 
  1. Values are presented as number (%). Hematological toxicity that developed within 28 days after CDDP administration was defined as grade ≥ 3 of WBC, PLT, ANC, or Hb. Statistical analyses were performed using the Fisher’s exact test