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Fig. 4 | Journal of Pharmaceutical Health Care and Sciences

Fig. 4

From: Metallothionein synthesis increased by Ninjin-yoei-to, a Kampo medicine protects neuronal death and memory loss after exposure to amyloid β1-42

Fig. 4

Neuronal death assessed by FJB staining is rescued by NYT diet. Brain slices were stained with FJB and DAPI. FJB fluorescence was measured in the granule cell layer (GCL) of mice surrounded by the dotted line 14 days after ICV injection of Aβ1-42 (left). Magnified images are the areas from the white square in FJB images. Bar; 50 µm. FJB positive cell number was counted in the GCL. The data (mean ± SEM) indicate FJB-positive cells in the unit area after injection of vehicle or Aβ1-42 (right). *, p < 0.05, vs. control/saline, ##, p < 0.01, vs. control/Aβ (Tukey’s test). control/saline, 12 slices from 4 mice; control/Aβ, 36 slices from 12 mice; NYT/Aβ, 10 slices from 4 mice

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