Fig. 5
Attenuated LTP by Aβ1-42 is ameliorated by NYT diet. LTP recording was performed 2 days after administration of NYT diet to rats. LTP was induced 1 h after local injection of saline (vehicle) and Aβ1-42 in saline into the dentate granule cell layer via an injection cannula as shown by the arrow (upper-left). Averaged PS amplitudes for the last 10 min were represented as the magnitude of LTP (upper-right). ***, p < 0.001, vs. control/saline; #, p < 0.05, vs. control/Aβ (Tukey’s test). Representative fEPSP recordings are shown at the time -70 min (before injection; black line), -20 min (after injection; grey line) and 60 min (after tetanic stimulation; red line) (lower). control/saline, n = 7 rats; control/Aβ, n = 7 rats; NYT/Aβ, n = 7 rats