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Table 3 Effect of total number of previous immune checkpoint inhibitor (ICI) doses and time from last ICI dose to COVID-19 diagnosis on the development of respiratory failure due to COVID-19

From: Immune checkpoint inhibitor therapy and elevated levels of C-reactive protein associated with COVID-19 aggravation in patients with lung cancer

 

Total (n = 19)

Respiratory failure (n = 12)

No respiratory failure (n = 7)

p value

Total number of times ICI has been administered in the past, Median (min − max)

7 (1 − 32)

5.5 (1 − 18)

16 (3 − 32)

0.07a)

Time from last dose of ICI to COVID-19 diagnosis, Median (min − max)

144 (10 − 420)

76 (10 − 274)

221 (163 − 420)

0.004a)*

  1. *P < 0.05 was considered statistically significant
  2. a) Mann − Whitney U test